AccessCounter
Display the number of DL of the yesterday/this month/last month/total ( Distinguish it in non-member / studies)
|
yesterday
|
69(1)
|
|
this month
|
23606(183)
|
|
last month
|
99667(626)
|
|
total
|
1669659(13395)
|
|
KURA >
C. 医薬保健学域・研究域／医・薬学部／医学系研究科 >
c10. 学術雑誌掲載論文（医・保健） >
1. 査読済論文（医学・保健） >
It is display the full text
|
| Title: | Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity |
| Authors: | Matsuzawa-Nagata, Naoto
Takamura, Toshinari
Ando, Hitoshi
Nakamura, Seiji
Kurita, Seiichiro
Misu, Hirofumi
Ota, Tsuguhito
Yokoyama, Masayoshi
Honda, Masao
Miyamoto, Ken-ichi
Kaneko, Shuichi
長田, 直人
篁, 俊成
栗田, 征一郎
御簾, 博文
太田, 嗣人
本多, 政夫
宮本, 謙一
金子, 周一 |
| Date of Issue: | Aug-2008 |
| Publisher: | Elsevier |
| Journal: | Metabolism: Clinical and Experimental |
| ISSN: | 0026-0495 |
| Volume: | 57 |
| Number: | 8 |
| Start page: | 1071 |
| End page: | 1077 |
| Abstract: | Insulin resistance is a key pathophysiological feature of metabolic syndrome. However, the initial events triggering the development of insulin resistance and its causal relations with dysregulation of glucose and fatty acids metabolism remain unclear. We investigated biological pathways that have the potential to induce insulin resistance in mice fed a high-fat diet (HFD). We demonstrate that the pathways for reactive oxygen species (ROS) production and oxidative stress are coordinately up-regulated in both the liver and adipose tissue of mice fed an HFD before the onset of insulin resistance through discrete mechanism. In the liver, an HFD up-regulated genes involved in sterol regulatory element binding protein 1c-related fatty acid synthesis and peroxisome proliferator-activated receptor α-related fatty acid oxidation. In the adipose tissue, however, the HFD down-regulated genes involved in fatty acid synthesis and up-regulated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. Furthermore, increased ROS production preceded the elevation of tumor necrosis factor-α and free fatty acids in the plasma and liver. The ROS may be an initial key event triggering HFD-induced insulin resistance. © 2008 Elsevier Inc. All rights reserved. |
| DOI: | 10.1016/j.metabol.2008.03.010 |
| URI: | http://hdl.handle.net/2297/11570 |
| Type: | Journal Article |
| Version: | author |
| Appears in Collections: | 1. 査読済論文（医学・保健）
|
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2297/11570
|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
|
