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タイトル: Progress in transduction of cerebellar Purkinje cells in vivo using viral vectors
著者: Hirai, Hirokazu
平井, 宏和
発行日: 2008年 9月
出版社(者): Springer-Verlag
雑誌名: The Cerebellum
ISSN: 1473-4222
巻: 7
号: 3
開始ページ: 273
終了ページ: 278
キーワード: adeno-associated virus
gene therapy
lentivirus
Purkinje cell
viral vector
抄録: Expression of a foreign gene in cerebellar Purkinje cells in vivo is a powerful method for exploring the pathophysiology of the cerebellum. Although using developmental engineering many gene-modified mice have been generated, this approach is time-consuming and requires a lot of effort for crossing different lines of mice, genotyping and maintenance of animals. If a gene of interest can be transferred to and efficiently expressed in Purkinje cells of developing and mature animals, it saves much time, effort and money. Recent advances in viral vectors have markedly contributed to selective and efficient gene transfer to Purkinje cells in vivo. There are two approaches for selective gene expression in Purkinje cells: one is to take advantage of the viral tropism for Purkinje cells, which includes the tropism of adeno-associated virus and the vesicular stomatitis virus glycoprotein (VSV-G)-pseudotyped lentivirus. Another method, which might be used in combination with the first one, is utilization of a Purkinje-cell-specific promoter. Focusing mainly on these points, recent progress in viralvector-mediated transduction of Purkinje cells in vivo is reviewed. © 2008 Springer Science+Business Media, LLC.
内容記述: This article has not been published yet.
DOI: 10.1007/s12311-008-0012-5
URI: http://hdl.handle.net/2297/11727
関連URI: http://dx.doi.org/10.1007/s12311-008-0012-5
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

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