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タイトル: Regional wall thickening in gated myocardial perfusion SPECT in a Japanese population: Effect of sex, radiotracer, rotation angles and frame rates
著者: Akhter, Nasima
Nakajima, Kenichi link image link image
Okuda, Koichi
Matsuo, Shinro link image link image
Yoneyama, Tatsuya
Taki, Junichi link image link image
Kinuya, Seigo link image link image
中嶋, 憲一
松尾, 信郎
米山, 達也
瀧, 淳一
絹谷, 清剛
発行日: 2008年 9月
出版社(者): Springer-Verlag
雑誌名: European journal of nuclear medicine
ISSN: 0340-6997
巻: 35
号: 9
開始ページ: 1608
終了ページ: 1615
キーワード: 201Tl
99mTc-sestamibi
Population specific standard
Quantitative gated SPECT
Regional myocardial thickening
抄録: Purpose: Gated single-photon emission computed tomography (SPECT) imaging of myocardium by 99mTc and 201Tl is used extensively to measure quantitative cardiac functional parameters. However, factors affecting normal values for myocardial functional parameters and population-specific standards have not yet been established. The aim of the study was to determine the effect of sex, radiotracer, rotation angles and frame rates on resting myocardial wall thickening (WT) and to develop a Japanese standard of normal values for WT. Methods: Data from a total of 202 patients with low possibility of having cardiac problems were collected from nine hospitals throughout Japan. Patients were divided into five groups according to study protocol, and WT was evaluated according to the 17-segment and four-region (basal, mid and apical regions and the apex) polar map distribution. Result: WT was generally higher in women than in men irrespective of the use of radiotracers, rotation angles or frame rates, and the difference was highly significant in the mid and apical regions. In any protocol used, resting myocardial thickening in the apex was higher than in the mid and apical regions, and thickening was lowest in the basal region, suggesting heterogeneous regional myocardial thickening (%) in normal subjects. Different rotation angles showed no significant change on WT, but different frame rates and tracers showed significant WT change in both sexes. Percent thickening of the myocardium was significantly higher in imaging by 99mTc-labelled tracers than in 201Tl. Conclusion: Sex, radiotracers and frame rates had a significant effect on myocardial thickening, and the importance of population-specific standards should be emphasized. A normal database can serve as a standard for gated SPECT evaluation of myocardial thickening in a Japanese population and might be applicable to Asian populations having a similar physique. © 2008 Springer-Verlag.
内容記述: This article has not been published yet.
DOI: 10.1007/s00259-008-0804-3
URI: http://hdl.handle.net/2297/11732
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

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