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タイトル: Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study
著者: Alam, Shamiul
Ueki, Koichiro
Nakagawa, Kiyomasa
Marukawa, Kohei
Hashiba, Yukari
Yamamoto, Etsuhide
Sakulsak, Natthiya
Iseki, Shoichi link image
上木, 耕一郎
中川, 清昌
丸川, 浩平
羽柴, 由香里
山本, 悦秀
井関, 尚一
発行日: 2009年 1月
出版社(者): Elsevier
雑誌名: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
ISSN: 1079-2104
巻: 107
号: 1
開始ページ: 22
終了ページ: 29
抄録: Objectives: The purpose of this study was to investigate bone morphogenetic protein (BMP) 2 expression after implantation of a statin and recombinant human BMP-2 (rhBMP-2) and to compare the bone regeneration capability of these substances in the rabbit nasal bone using immunohistologic methods. Study design: Twelve adult male Japanese white rabbits (n = 12; age 12-16 weeks, weight 2.5-3.0 kg) were divided into 3 experimental groups and 1 control group. A total of 48 bone defects, 4 per rabbit, were created in the nasal bone while preserving the nasal membrane. In the experimental groups, 1 group was implanted with 10 mg of a statin dissolved in 0.2 mL water with an atelocollagen sponge (ACS); the second group was implanted with 5 μg rhBMP-2 with an ACS; and in the third group only the ACS was implanted. No material was implanted in the control group. Animals were killed at 1, 2, and 4 weeks after surgery. The parts that had been operated on were removed and prepared for histologic assessment. The expression of BMP-2 was evaluated using immunohistochemistry, and double-immunostaining for BMP-2 and Ki-67 was observed by fluorescent microscopy. Results: No significant differences were observed between the statin/ACS group and rhBMP-2/ACS group at 1, 2, and 4 weeks after surgery. The number of cells which stained positively for BMP-2 increased significantly in both of the implanted groups compared with the control group (P < .0001). The positive fluorescent double-immunostaining for BMP-2 and Ki-67 was similar in both implanted groups. Conclusion: This study suggests that statin/ACS implants show BMP-2 expression and osteoinductive activity that is similar to those of rhBMP-2/ACS implants. © 2009 Mosby, Inc. All rights reserved..
DOI: 10.1016/j.tripleo.2008.06.025
URI: http://hdl.handle.net/2297/14394
関連URI: http://dx.doi.org/10.1016/j.tripleo.2008.06.025
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

このアイテムを引用あるいはリンクする場合は次の識別子を使用してください。 http://hdl.handle.net/2297/14394



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