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タイトル: Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study
著者: Alam, Shamiul
Ueki, Koichiro
Nakagawa, Kiyomasa
Marukawa, Kohei
Hashiba, Yukari
Yamamoto, Etsuhide
Sakulsak, Natthiya
Iseki, Shoichi link image
上木, 耕一郎
中川, 清昌
丸川, 浩平
羽柴, 由香里
山本, 悦秀
井関, 尚一
発行日: 2009年 1月
出版社(者): Elsevier
雑誌名: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
ISSN: 1079-2104
巻: 107
号: 1
開始ページ: 22
終了ページ: 29
抄録: Objectives: The purpose of this study was to investigate bone morphogenetic protein (BMP) 2 expression after implantation of a statin and recombinant human BMP-2 (rhBMP-2) and to compare the bone regeneration capability of these substances in the rabbit nasal bone using immunohistologic methods. Study design: Twelve adult male Japanese white rabbits (n = 12; age 12-16 weeks, weight 2.5-3.0 kg) were divided into 3 experimental groups and 1 control group. A total of 48 bone defects, 4 per rabbit, were created in the nasal bone while preserving the nasal membrane. In the experimental groups, 1 group was implanted with 10 mg of a statin dissolved in 0.2 mL water with an atelocollagen sponge (ACS); the second group was implanted with 5 μg rhBMP-2 with an ACS; and in the third group only the ACS was implanted. No material was implanted in the control group. Animals were killed at 1, 2, and 4 weeks after surgery. The parts that had been operated on were removed and prepared for histologic assessment. The expression of BMP-2 was evaluated using immunohistochemistry, and double-immunostaining for BMP-2 and Ki-67 was observed by fluorescent microscopy. Results: No significant differences were observed between the statin/ACS group and rhBMP-2/ACS group at 1, 2, and 4 weeks after surgery. The number of cells which stained positively for BMP-2 increased significantly in both of the implanted groups compared with the control group (P < .0001). The positive fluorescent double-immunostaining for BMP-2 and Ki-67 was similar in both implanted groups. Conclusion: This study suggests that statin/ACS implants show BMP-2 expression and osteoinductive activity that is similar to those of rhBMP-2/ACS implants. © 2009 Mosby, Inc. All rights reserved..
DOI: 10.1016/j.tripleo.2008.06.025
URI: http://hdl.handle.net/2297/14394
関連URI: http://dx.doi.org/10.1016/j.tripleo.2008.06.025
http://www.elsevier.com/locate/issn/10792104
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

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