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タイトル: The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis
著者: Ando, Hitoshi
Takamura, Toshinari link image link image
Matsuzawa-Nagata, Naoto
Shima, Kosuke R.
Nakamura, Seiji
Kumazaki, Masafumi
Kurita, Seiichiro
Misu, Hirofumi link image link image
Togawa, Naoyuki
Fukushima, Tatsunobu
Fujimura, Akio
Kaneko, Shuichi link image link image
安藤, 仁
篁, 俊成
長田, 直人
島, 孝佑
御簾, 博文
金子, 周一
発行日: 2009年 3月13日
出版社(者): Elsevier
雑誌名: Biochemical and Biophysical Research Communications
ISSN: 0006-291X
巻: 380
号: 3
開始ページ: 684
終了ページ: 688
キーワード: Atherogenic diet
Circadian rhythm
Clock gene
Non-alcoholic steatohepatitis
Oxidative stress
抄録: Recent studies have correlated metabolic diseases, such as metabolic syndrome and non-alcoholic fatty liver disease, with the circadian clock. However, whether such metabolic changes per se affect the circadian clock remains controversial. To address this, we investigated the daily mRNA expression profiles of clock genes in the liver of a dietary mouse model of non-alcoholic steatohepatitis (NASH) using a custom-made, high-precision DNA chip. C57BL/6J mice fed an atherogenic diet for 5 weeks developed hypercholesterolemia, oxidative stress, and NASH. DNA chip analyses revealed that the atherogenic diet had a great influence on the mRNA expression of a wide range of genes linked to mitochondrial energy production, redox regulation, and carbohydrate and lipid metabolism. However, the rhythmic mRNA expression of the clock genes in the liver remained intact. Most of the circadianly expressed genes also showed 24-h rhythmicity. These findings suggest that the biological clock is protected against such a metabolic derangement as NASH. © 2009 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.bbrc.2009.01.150
URI: http://hdl.handle.net/2297/17062
関連URI: http://www.elsevier.com/locate/issn/0006291X
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

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