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タイトル: Standardization of the heart-to-mediastinum ratio of 123I- labelled-metaiodobenzylguanidine uptake using the dual energy window method: Feasibility of correction with different camera-collimator combinations
著者: Matsuo, Shinro link image link image
Nakajima, Kenichi link image link image
Okuda, Koichi
Kawano, Masaya
Ishikawa, Takehiro
Hosoya, Tetsuo
Taki, Junichi link image link image
Kinuya, Seigo link image link image
松尾, 信郎
中嶋, 憲一
瀧, 淳一
絹谷, 清剛
発行日: 2009年 4月
出版社(者): Springer Verlag (Germany)
雑誌名: European Journal of Nuclear Medicine and Molecular Imaging
ISSN: 1619-7070
巻: 36
号: 4
開始ページ: 560
終了ページ: 566
キーワード: Cardiology MIBG
Gamma cameras
Imaging
Iodine
MIBG heart failure
Nuclear imaging detectors
抄録: Background: Although the heart-to-mediastinum (H/M) ratio in a planar image has been used for practical quantification in 123I- metaiodobenzylguanidine (MIBG) imaging, standardization of the parameter is not yet established. We hypothesized that the value of the H/M ratio could be standardized to the various camera-collimator combinations. Methods and results: Standard phantoms consisting of the heart and mediastinum were made. A low-energy high-resolution (LEHR) collimator and a medium-energy (ME) collimator were used. We examined multi-window correction methods with 123I- dual-window (IDW) acquisition, and planar images were obtained with IDW correction and the LEHR collimator. The images were obtained using the following gamma camera systems: GCA 9300A (Toshiba, Tokyo), E.CAM Signature (Toshiba/Siemens, Tokyo) and Varicam (GE, Tokyo). Cardiac phantom studies demonstrated that contamination of the H/M count ratio was greater with the LEHR collimator and least with the ME collimator. The corrected H/M ratio with the LEHR collimator was similar to that with ME collimators. The uncorrected H/M ratio with the ME collimator was linearly related to the H/M ratio with IDW correction with the LEHR collimator. The relationship between the uncorrected H/M ratios determined with the LEHR (E.CAM) and the ME collimators was y = 0.56x + 0.49, where y = H/M ratio with the E.CAM and x = H/M ratio with the ME collimator. The average normal values for the low-energy collimator (n=18) were 2.2±0.2 (initial H/M ratio) and 2.42±0.2 (delayed H/M ratio), and for the low/medium-energy (LME) collimator (n=14) were 2.63±0.25 (initial H/M ratio) and 2.87±0.19 (delayed H/M ratio). H/M ratios in previous clinical studies using LEHR collimators are comparable to those with ME collimators. Conclusion: The IDW-corrected H/M ratios determined with the LEHR collimator were similar to those determined with the ME collimator. This finding could make it possible to standardize the H/M ratio in planar imaging among various collimators in the clinical setting. © 2008 Springer-Verlag.
DOI: 10.1007/s00259-008-0971-2
URI: http://hdl.handle.net/2297/17352
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文

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