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タイトル: Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses
著者: Nakamura, Mitsuhiro link image link image
Bodily, Jason M.
Beglina, Melanie
Kyo, Satoru link image
Inoue, Masaki link image
Laimins, Laimonis A.
中村, 充宏
京, 哲
井上, 正樹
発行日: 2009年 5月10日
出版社(者): Elsevier
雑誌名: Virology
ISSN: 0042-6822
巻: 387
号: 2
開始ページ: 442
終了ページ: 448
キーワード: Angiogenesis
Carbonic anhydrase (CAIX)
Deferoxamine mesylate (DFO)
Hypoxia
Hypoxia inducible factor-1 (HIF-1)
Keratinocytes
Papillomaviruses (HPV)
Vascular endothelial growth factor (VEGF)
抄録: Human papillomaviruses (HPV) are the causative agents of cervical cancer and have been shown to increase expression of pro-angiogenic factors from infected cells. Many angiogenic factors are regulated by hypoxia inducible factor 1α (HIF-1α). We investigated whether HPV31 affects the levels of HIF-1α under normal and hypoxic conditions. Our studies indicate that cells containing complete HPV31 genomes showed enhanced levels of HIF-1α upon treatment with the hypoxia mimic DFO, which resulted from protein stabilization and led to increased expression of some but not all HIF-1α target genes. Both HPV E6 and E7 were able independently to enhance induction of HIF-1α upon DFO treatment. Enhancement of HIF-1α stability was not restricted to high-risk HPV types, as HPV11, a low risk HPV type, mediated a similar effect. These findings shed light on mechanisms by which HPV contributes to angiogenesis both in benign cervical lesions and in cervical cancers. © 2009 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.virol.2009.02.036
URI: http://hdl.handle.net/2297/17396
関連URI: http://www.elsevier.com/locate/issn/00426822
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文

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