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タイトル: Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses
著者: Nakamura, Mitsuhiro link image link image
Bodily, Jason M.
Beglina, Melanie
Kyo, Satoru link image
Inoue, Masaki link image
Laimins, Laimonis A.
中村, 充宏
京, 哲
井上, 正樹
発行日: 2009年 5月10日
出版社(者): Elsevier
雑誌名: Virology
ISSN: 0042-6822
巻: 387
号: 2
開始ページ: 442
終了ページ: 448
キーワード: Angiogenesis
Carbonic anhydrase (CAIX)
Deferoxamine mesylate (DFO)
Hypoxia inducible factor-1 (HIF-1)
Papillomaviruses (HPV)
Vascular endothelial growth factor (VEGF)
抄録: Human papillomaviruses (HPV) are the causative agents of cervical cancer and have been shown to increase expression of pro-angiogenic factors from infected cells. Many angiogenic factors are regulated by hypoxia inducible factor 1α (HIF-1α). We investigated whether HPV31 affects the levels of HIF-1α under normal and hypoxic conditions. Our studies indicate that cells containing complete HPV31 genomes showed enhanced levels of HIF-1α upon treatment with the hypoxia mimic DFO, which resulted from protein stabilization and led to increased expression of some but not all HIF-1α target genes. Both HPV E6 and E7 were able independently to enhance induction of HIF-1α upon DFO treatment. Enhancement of HIF-1α stability was not restricted to high-risk HPV types, as HPV11, a low risk HPV type, mediated a similar effect. These findings shed light on mechanisms by which HPV contributes to angiogenesis both in benign cervical lesions and in cervical cancers. © 2009 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.virol.2009.02.036
URI: http://hdl.handle.net/2297/17396
関連URI: http://www.elsevier.com/locate/issn/00426822
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文

このアイテムを引用あるいはリンクする場合は次の識別子を使用してください。 http://hdl.handle.net/2297/17396



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