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タイトル: Association of phosphorylation site of tau protein with neuronal apoptosis in Alzheimer's disease
著者: Kobayashi, Katsuji link image
Nakano, Hiroyuki
Hayashi, Masahiro
Shimazaki, Masao
Fukutani, Yuken
Sasaki, Kazuo
Sugimori, Kaoru
Koshino, Yoshifumi
小林, 克治
発行日: 2003年 4月
出版社(者): Elsevier
引用: Journal of the Neurological Sciences 208 (1-2), pp.17-24
雑誌名: Journal of the Neurological Sciences
ISSN: 0022-510X
1-2
巻: 208
開始ページ: 17
終了ページ: 24
キーワード: Alzheimer's disease
Apoptosis
Neurofibrillary tangles
Pretangle neurons
TUNEL
抄録: In addition to neuritic changes and amyloid deposits, neuronal and glial cell apoptosis is an important pathological feature of Alzheimer's disease (AD). Several factors have been postulated as causes or triggers of cellular apoptotic change. This study focused on a quantifiable relationship between phosphorylation sites of tau protein in the neurofibrillary tangles (NFT) and neuronal apoptosis. Five monoclonal anti-tau antibodies (AT180, AT8, HT7, Tau2 and Tau5) for NFT labeling and TdT-mediated UTP nick-end labeling (TUNEL) for localizing apoptotic change were employed. TUNEL-stained neuronal nuclei showed significantly high density in the entorhinal cortex, cornu ammonis (CA) and the parietal cortex. In all regions, density of TUNEL-stained neuronal nuclei showed significantly direct correlation with that of AT8-, AT180- and Tau2-positive neurons. Correlation of TUNEL-stained neuronal nuclei with tau-positive neurons differed depending on the cerebral regions. Density of TUNEL-stained neuronal nuclei showed inverse correlation with that of both AT8-positive and Gallyas-stained NFT in the CA and showed significantly direct correlation with AT8- and HT7-positive neurons in the frontal cortex. Density of tau-positive and Gallyas-stained NFT was higher than that of TUNEL-stained nuclei. We conclude that phosphorylation sites of tau, 159-163 and 202-205, are probably associated with neuronal apoptosis and apoptotic change follows abnormal phosphorylation of tau.
URI: http://hdl.handle.net/2297/1795
関連URI: http://dx.doi.org/10.1016/S0022-510X(02)00410-0
http://www.elsevier.com/locate/inca/506078
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

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