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タイトル: Loss of maspin is a negative prognostic factor for invasion and metastasis in oral squamous cell carcinoma
著者: Yoshizawa, Kunio link image link image
Nozaki, Shinichi
Okamune, Ayako
Kitahara, Hiroko
Ohara, Teruhisa
Kato, Koroku
Kawashiri, Shuichi link image link image
Yamamoto, Etsuhide
吉澤, 邦夫
岡宗, 絢子
北原, 寛子
川尻, 秀一
山本, 悦秀
発行日: 2009年 7月
出版社(者): John Wiley & Sons
雑誌名: Journal of Oral Pathology and Medicine
ISSN: 0904-2512
巻: 38
号: 6
開始ページ: 535
終了ページ: 539
キーワード: Carcinoma
Maspin
Oral squamous cell
Serine protease inhibitor
Tumor suppressor
抄録: Objective: Maspin, a 42-kDa protein, belongs to the serpin family of protease inhibitors and is known to have tumor-suppressor function. In this study, we investigated the interrelationship between clinicopathologic findings and maspin expression in oral squamous cell carcinoma (OSCC). Methods: Using immunohistochemical techniques to examine the expression levels of maspin in OSCC, maspin expression in OSCC was detected in 46 (64.8%) of 71 cases. We also compared the clonicopathologic features of OSCC cases with maspin expression levels. Moreover, we examined expression of maspin in eight cell lines derived from OSCC using reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting. Results: There was a significant correlation between decreased maspin expression and T-category (P < 0.01), lymph metastasis (P < 0.0001), and mode of invasion (P < 0.0001). Patients with positive maspin expression had a significantly better prognosis (P < 0.001). Lower expression of maspin was also seen in cell lines derived from grade 4D, which shows stronger invasive potential than other grades of OSCC. Conclusion: Maspin may be a useful marker to identify the potential for progression in OSCC. © 2008 Blackwell Munksgaard.
DOI: 10.1111/j.1600-0714.2009.00762.x
URI: http://hdl.handle.net/2297/19312
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文

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