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タイトル: Prevention of pin tract infection with titanium-copper alloys
著者: Shirai, Toshiharu
Tsuchiya, Hiroyuki link image link image
Shimizu, Tohru
Ohtani, Kaori
Zen, Yoh
Tomita, Katsuro
白井, 寿治
土屋, 弘行
清水, 徹
大谷, 郁
全, 陽
富田, 勝郎
発行日: 2009年10月
出版社(者): John Wiley & Sons / 日本バイオマテリアル学会
雑誌名: Journal of Biomedical Materials Research - Part B Applied Biomaterials
ISSN: 1552-4973
巻: 91
号: 1
開始ページ: 373
終了ページ: 380
キーワード: Antibacterial
Biocompatibility
Cytotoxicity
Pin tract infection
Titanium-copper alloy
抄録: The most frequent complication in external fixation is pin tract infection. To reduce the incidence of implant-associated infection, many published reports have looked at preventing bacterial adhesion by treating the pin surface. This study aimed to evaluate the antibacterial activity of a Titanium-Copper (Ti-Cu) alloy on implant infection, and to determine the potential use of the Ti-Cu alloy as a biomaterial. Two forms of Ti-Cu alloys were synthesized: one with 1% Cu and the other with 5% Cu. For analyzing infectious behavior, the implants were exposed to Staphylococcus aureus and Escherichia coli. The reaction of pathogens to the Ti-Cu alloys was compared with their reaction to stainless steel and pure titanium as controls. Both Ti-Cu alloys evidently inhibited colonization by both bacteria. Conversely, cytocompatibility studies were performed using fibroblasts and colony formation on the metals was assessed by counting the number of colonies. Ti-1% Cu alloy showed no difference in the number of colonies compared with the control. External fixator pins made of Ti-Cu alloys were evaluated in a rabbit model. The tissue-implant interactions were analyzed for the presence of infection, inflammatory changes and osteoid-formation. Ti-1% Cu alloy significantly inhibited inflammation and infection, and had excellent osteoid-formation. Copper blood levels were measured before surgery and at 14 days postoperatively. Preoperative and postoperative blood copper values were not statistically different. Overall, it was concluded that Ti-Cu alloys have antimicrobial activity and substantially reduce the incidence of pin tract infection. Ti-1% Cu alloy shows particular promise as a biomaterial. © 2009 Wiley Periodicals, Inc.
DOI: 10.1002/jbm.b.31412
URI: http://hdl.handle.net/2297/19630
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

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