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タイトル: Advanced hepatocellular carcinoma treated effectively with irinotecan via hepatic arterial infusion followed by proton beam therapy
著者: Ohtsubo, Koushiro link image link image
Watanabe, Hiroyuki
Tsuchiyama, Tomoya
Mouri, Hisatsugu
Yamaguchi, Yasushi
Motoo, Yoshiharu
Okai, Takashi
Sanada, Junichiro
Matsui, Osamu
Kitamura, Tokuji
Fujiki, Ryusuke
Tokuuye, Koichi
Sawabu, Norio
大坪, 公士郎
渡邊, 弘之
毛利, 久継
眞田, 順一郎
松井, 修
澤武, 紀雄
発行日: 2009年10月
出版社(者): Springer Verlag (Germany) / 日本化学療法学会
雑誌名: Journal of Infection and Chemotherapy
ISSN: 1341-321X
巻: 15
号: 5
開始ページ: 316
終了ページ: 321
キーワード: Docetaxel
Hepatic arterial infusion
Hepatocellular carcinoma
Hyperthermia
Irinotecan
Proton beam therapy
抄録: We report a 48-year-old man with hepatocellular carcinoma (HCC) treated with hepatic arterial infusion (HAI) chemotherapy followed by proton beam therapy. The HCC lesion in this patient was 88 mm in diameter, with portal vein tumor thrombosis in the right lobe of the liver. He was first treated with 5-fluorouracil, cisplatin, and isovorin, administered by HAI, combined with interferon-α, and he was subsequently treated with epirubicin and mitomycin-C administered by HAI. However, no definite efficacy of either of these treatments was observed. Then, after 3 weeks' continuous administration of irinotecan by HAI, the tumor size decreased to 68 mm in diameter. However, 3 months after reduction of the tumor, the tumor had become enlarged to 100 mm in diameter and intrahepatic metastases were prominent. Angiographic findings indicated that the HCC was fed not only from the right hepatic artery but also from the left gastric and right and left subphrenic arteries. After rearrangement of the arteries, and 3 months' continuous HAI chemotherapy with irinotecan, plus hyperthermia, the tumor size had decreased to 50 mm in diameter. The reduction rate of the main tumor according to the Response Evaluation Criteria in Solid Tumors was 43%; therefore, the efficacy of this treatment was judged as a partial response. Two months after reduction of the tumor, the patient's serum alpha-fetoprotein (AFP) level was elevated, and so docetaxel was administered by HAI instead of irinotecan. The liver tumors showed gradual enlargement during the administration of docetaxel, although the AFP level was suppressed. Proton beam therapy was instituted and the liver tumors showed necrosis after this therapy. The patient died of hepatic failure and distant metastases 6 years after the onset of HCC. As far as we know, this is the first case report of HCC treated effectively with irinotecan administered by HAI followed by proton beam therapy in which tumor suppression and the long-term survival of the patient were observed. © 2009 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
DOI: 10.1007/s10156-009-0702-z
URI: http://hdl.handle.net/2297/19911
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文

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