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タイトル: Flow cytometric analysis of skin blister fluid induced by mosquito bites in a patient with chronic active Epstein-Barr virus infection
著者: Wada, Taizo link image link image
Yokoyama, Tadafumi
Nakagawa, Hiroyasu
Asai, Erika
Taga, Akiko
Sakakibara, Yasuhisa
Shibata, Fumie
Tone, Yumi
Shimizu, Masaki link image link image
Toma, Tomoko link image link image
Yachie, Akihiro link image link image
和田, 泰三
浅井, 絵利香
清水, 正樹
東馬, 智子
谷内江, 昭宏
発行日: 2009年12月
出版社(者): The Japanese Society of Hematology = 日本血液学会
雑誌名: International Journal of Hematology
ISSN: AA10797094
0925-5710
巻: 90
号: 5
開始ページ: 611
終了ページ: 615
キーワード: CD203c
Chronic active Epstein-Barr virus infection
Mosquito bites
NK cells
Skin blister
抄録: In chronic active Epstein-Barr virus (EBV) infection (CAEBV), ectopic EBV infection has been described in T or natural killer (NK) cells. NK cell-type infection (NK-CAEBV) is characterized by large granular lymphocytosis, high IgE levels and unusual reactions to mosquito bites, including severe local skin reactions, fever and liver dysfunction. However, the mechanisms underlying these reactions remain undetermined. Herein, we describe a patient with NK-CAEBV whose blister fluid after mosquito bites was analyzed. The patient exhibited significant increases in the percentage of CD56+ NK cells in the fluid compared with a simple mosquito allergy, in which the majority of infiltrated cells were CD203c+ cells, indicating basophils and/or mast cells. His fluid also contained CD203c+ cells, and his circulating basophils were activated by mosquito extracts in vitro. These results suggest that CD203c+ cells as well as NK cells may play pathogenic roles in the severe skin reactions to mosquito bites in NK-CAEBV. © 2009 The Japanese Society of Hematology.
内容記述: 出版者に照会中.2010年12月より全文公開予定.
DOI: 10.1007/s12185-009-0442-y
URI: http://hdl.handle.net/2297/20517
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

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