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タイトル: Interleukin-6 upregulates the expression of PMP22 in cultured rat Schwann cells via a JAK2-dependent pathway
著者: Ito, Takaaki
Ikeda, Kazuo link image
Tomita, Katsuro link image
Yokoyama, Shigeru link image link image
伊藤, 貴明
池田, 和夫
富田, 勝郎
横山, 茂
発行日: 2010年 3月19日
出版社(者): Elsevier
雑誌名: Neuroscience Letters
ISSN: 0304-3940
巻: 472
号: 2
開始ページ: 104
終了ページ: 108
キーワード: gp130
Peripheral myelin protein 22
Schwann cell
抄録: The interleukin-6 (IL-6) family of cytokines is thought to be involved in the development and regeneration of peripheral nerves; however, their roles in myelination remain unclear. In this study, we examined the effects of IL-6 on the expression of genes for compact myelin proteins using Schwann cell cultures prepared by multiple explantation of adult rat sciatic nerves. In semi-quantitative reverse transcription-polymerase chain reaction analysis, stimulation of Schwann cells with IL-6 significantly increased the mRNA level of peripheral myelin protein 22 (PMP22), but not those of myelin protein zero and myelin basic protein. The increase in PMP22 mRNA was markedly suppressed by AG490, a Janus kinase 2 (JAK2) inhibitor, but not significantly by PD098059, a mitogen-activated protein kinase inhibitor. Immunocytochemical staining revealed that IL-6 enhanced immunoreactivities for the phosphorylated forms of both JAK2 and signal transducer and activator of transcription 3 (STAT3), as well as that for PMP22. These results indicate that IL-6 can enhance PMP22 production in Schwann cells via a JAK2-dependent pathway by probably activating STAT3 and thus may contribute to myelination. © 2010 Elsevier Ireland Ltd. All rights reserved.
DOI: 10.1016/j.neulet.2010.01.061
URI: http://hdl.handle.net/2297/21587
関連URI: http://www.elsevier.com/locate/issn/03043940
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

このアイテムを引用あるいはリンクする場合は次の識別子を使用してください。 http://hdl.handle.net/2297/21587



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