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タイトル: MT1-MMP promotes cell growth and ERK activation through c-Src and paxillin in three-dimensional collagen matrix
著者: Takino, Takahisa link image link image
Tsuge, Hisashi
Ozawa, Terumasa
Sato, Hiroshi link image
滝野, 隆久
佐藤, 博
発行日: 2010年 6月
出版社(者): Elsevier
雑誌名: Biochemical and Biophysical Research Communications
ISSN: 0006-291X
巻: 396
号: 4
開始ページ: 1042
終了ページ: 1047
キーワード: Cancer
抄録: Membrane-type 1 matrix metalloproteinase (MT1-MMP) is essential for tumor invasion and growth. We show here that MT1-MMP induces extracellular signal-regulated kinase (ERK) activation in cancer cells cultured in collagen gel, which is indispensable for their proliferation. Inhibition of MT1-MMP by MMP inhibitor or small interfering RNA suppressed activation of focal adhesion kinase (FAK) and ERK in MT1-MMP-expressing cancer cells, which resulted in up-regulation of p21WAF1 and suppression of cell growth in collagen gel. Cell proliferation was also abrogated by the inhibitor against ERK pathway without affecting FAK phosphorylation. MT1-MMP and integrin αvβ3 were shown to be involved in c-Src activation, which induced FAK and ERK activation in collagen gel. These MT1-MMP-mediated signal transductions were paxillin dependent, as knockdown of paxillin reduced cell growth and ERK activation, and co-expression of MT1-MMP with paxillin induced ERK activation. The results suggest that MT1-MMP contributes to proliferation of cancer cells in the extracellular matrix by activating ERK through c-Src and paxillin. © 2010 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.bbrc.2010.05.059
URI: http://hdl.handle.net/2297/24574
関連URI: http://www.elsevier.com/locate/issn/0006291X
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文

このアイテムを引用あるいはリンクする場合は次の識別子を使用してください。 http://hdl.handle.net/2297/24574



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