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タイトル: An experimental study of use of absorbable plate in combination with self-setting α-tricalcium phosphate for orthognathic surgery
著者: Okabe, Katsuhiko
Ueki, Koichiro link image
Marukawa, Kohei
Mukozawa, Aya
Miyazaki, Mao
Nakagawa, Kiyomasa link image
岡部, 克彦
上木, 耕一郎
丸川, 浩平
宮﨑, 真凡
中川, 清昌
発行日: 2010年11月
出版社(者): Elsevier
雑誌名: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
ISSN: 1079-2104
巻: 110
号: 5
開始ページ: 560
終了ページ: 569
抄録: Objective: The purpose of this study was to histologically and immunohistochemically evaluate bone formation using both self-setting α-tricalcium phosphate (α-TCP; Biopex) and absorbable plate (Super Fixsorb-MX) in rabbit cranium bone. Study design: Twelve adult male Japanese white rabbits (12-16 wk, 2.5-3.0 kg) were used. The surgical defects were made in the nasal bone of a rabbit, and Biopex was implanted in the left side and no material in the right side. Two-hole absorbable plate and 2 screws (Super Fixsorb-MX) were fixed across the defect in each side. The rabbits were killed at 1, 4, 12, and 24 weeks after surgery, and formalin-fixed specimens were embedded in acrylic resin. The specimens were stained with hematoxylin and eosin. For immunohistochemical analysis, the specimens were treated with bone morphogenetic protein 2 (BMP-2) antibodies. Finally, these were evaluated microscopically. Results: New bone formation was observed in the region of absorbable plate and nasal membrane after >4 weeks. The area of new bone with Biopex was significantly larger than that of the control side after 1, 4, and 12 weeks (P < .05). The number of BMP-2-stained cells in the experimental side was significantly larger than in the control side after 4 and 12 weeks (P < .05). Conclusion: This study suggests that the use of absorbable plate (Super Fixsorb-MX) in combination with Biopex could be useful and that both of Super Fixsorb-MX and Biopex could provide adequate bone regeneration. © 2010 Mosby, Inc. All rights reserved.
URI: http://hdl.handle.net/2297/24575
関連URI: http://www.elsevier.com/locate/issn/10792104
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

このアイテムを引用あるいはリンクする場合は次の識別子を使用してください。 http://hdl.handle.net/2297/24575



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