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タイトル: An experimental study of use of absorbable plate in combination with self-setting α-tricalcium phosphate for orthognathic surgery
著者: Okabe, Katsuhiko
Ueki, Koichiro link image
Marukawa, Kohei
Mukozawa, Aya
Miyazaki, Mao
Nakagawa, Kiyomasa link image
岡部, 克彦
上木, 耕一郎
丸川, 浩平
宮﨑, 真凡
中川, 清昌
発行日: 2010年11月
出版社(者): Elsevier
雑誌名: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
ISSN: 1079-2104
10.1016/j.tripleo.2010.02.033
巻: 110
号: 5
開始ページ: 560
終了ページ: 569
抄録: Objective: The purpose of this study was to histologically and immunohistochemically evaluate bone formation using both self-setting α-tricalcium phosphate (α-TCP; Biopex) and absorbable plate (Super Fixsorb-MX) in rabbit cranium bone. Study design: Twelve adult male Japanese white rabbits (12-16 wk, 2.5-3.0 kg) were used. The surgical defects were made in the nasal bone of a rabbit, and Biopex was implanted in the left side and no material in the right side. Two-hole absorbable plate and 2 screws (Super Fixsorb-MX) were fixed across the defect in each side. The rabbits were killed at 1, 4, 12, and 24 weeks after surgery, and formalin-fixed specimens were embedded in acrylic resin. The specimens were stained with hematoxylin and eosin. For immunohistochemical analysis, the specimens were treated with bone morphogenetic protein 2 (BMP-2) antibodies. Finally, these were evaluated microscopically. Results: New bone formation was observed in the region of absorbable plate and nasal membrane after >4 weeks. The area of new bone with Biopex was significantly larger than that of the control side after 1, 4, and 12 weeks (P < .05). The number of BMP-2-stained cells in the experimental side was significantly larger than in the control side after 4 and 12 weeks (P < .05). Conclusion: This study suggests that the use of absorbable plate (Super Fixsorb-MX) in combination with Biopex could be useful and that both of Super Fixsorb-MX and Biopex could provide adequate bone regeneration. © 2010 Mosby, Inc. All rights reserved.
URI: http://hdl.handle.net/2297/24575
関連URI: http://www.elsevier.com/locate/issn/10792104
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

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