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タイトル: Increased expression of deoxyribonucleic acid methyltransferase gene in human astrocytic tumors
著者: Okada, Yoshie
Okada, Takashi
Nomura, Masayuki
Hayashi, Yutaka link image
Yamashima, Tetsumori link image
Yamashita, Junkoh
林, 裕
山嶋, 哲盛
山下, 純宏
発行日: 2000年
出版社(者): 日本脳神経外科学会
雑誌名: Neurologia Medico-Chirurgica
ISSN: 0470-8105
巻: 40
号: 11
開始ページ: 564
終了ページ: 571
キーワード: Deoxyribonucleic acid methyltransferase
Glioma
In situ hybridization
Semiquantitative reverse transcriptase-polymerase chain reaction
抄録: The relationship between the grade of astrocytic tumor and the expression of deoxyribonucleic acid methyltransferase (DNA-MTase) gene was examined. The levels of DNA-MTase messenger ribonucleic acid (mRNA) were measured by semiquantitative reverse transcriptase-polymerase chain reaction in surgical specimens from 12 astrocytic tumors (4 astrocytomas, 6 anaplastic astrocytomas, and 2 glioblastomas) and two normal brain tissues, and in four glioma cell lines. Compared to normal brain tissues, the levels of DNA-MTase mRNA were increased by 16- to 55-fold in low grade astrocytomas, and significantly increased by 200- to 4500-fold in high grade astrocytomas (anaplastic astrocytomas and glioblastomas) and more than 4500-fold in glioma cell lines. In situ hybridization with paraffin-embedded surgical specimens of human astrocytic tumors showed DNA-MTase mRNA was abundantly expressed in high grade astrocytomas. The detection of increased DNA-MTase expression in astrocytic tumor indicates involvement in the tumorigenesis and suggests that blocking of this change with specific inhibitors may offer new therapeutic strategies for malignant astrocytic tumors.
DOI: 10.2176/nmc.40.564
URI: http://hdl.handle.net/2297/25178
関連URI: http://jns.umin.ac.jp/
http://www.jstage.jst.go.jp/article/nmc/40/11/40_564/_article
資料種別: Journal Article
権利関係: Copyright© The Japan Neurosurgical Society
版表示: publisher
出現コレクション:1. 査読済論文(医学・保健)

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