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タイトル: Mouse models of gastric tumors: Wnt activation and PGE<sub>2</sub> induction
著者: Oshima, Hiroko link image link image
Oshima, Masanobu link image link image
大島, 浩子
大島, 正伸
発行日: 2010年 9月
出版社(者): Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd / 日本病理学会
雑誌名: Pathology International
ISSN: 1320-5463
巻: 60
号: 9
開始ページ: 599
終了ページ: 607
キーワード: gastric cancer
mouse model
PGE2
Wnt
抄録: Accumulating evidence has suggested that cooperation of oncogenic activation and the host responses is important for cancer development. In gastric cancer, activation of Wnt signaling appears to be a major oncogenic pathway that causes tumorigenesis. In the chronic gastritis caused by Helicobacter pylori infection, cyclooxigenase-2 induces prostaglandin E 2 (PGE2) biosythesis, which plays an important role in tumorigenesis. We constructed a series of mouse models and investigated the role of each pathway in the gastric tumorigenesis. Wnt activation in gastric epithelial cells suppresses differentiation, and induces development of preneoplastic lesions. On the other hand, induction of the PGE2 pathway in gastric mucosa induces development of spasmolytic polypeptide-expressing metaplasia (SPEM), which is a possible preneoplastic metaplasia. Importantly, simultaneous activation of Wnt and PGE2 pathways leads to dysplastic gastric tumor development. Moreover, induction of the PGE2 pathway also promotes gastric hamartoma development when bone morphogenetic protein (BMP) signaling is suppressed. These results indicate that alteration in the Wnt or BMP signaling impairs epithelial differentiation, and the PGE2 pathway accelerates tumor formation regardless of the types of oncogenic pathways. We review the phenotypes and gene expression profiles of the respective models, and discuss the cooperation of oncogenic pathways and host responses in gastric tumorigenesis. Copyright © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
DOI: 10.1111/j.1440-1827.2010.02567.x
URI: http://hdl.handle.net/2297/25215
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文

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