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タイトル: Serum levels of KL-6 reflect disease activity of interstitial pneumonia associated with ANCA-related vasculitis
著者: Iwata, Yasunori link image link image
Wada, Takashi link image link image
Furuichi, Kengo link image link image
Kitagawa, Kiyoki link image link image
Kokubo, Satoshi
Kobayashi, Motoo
Sakai, Norihiko link image link image
Yoshimoto, Keiichi
Shimizu, Miho
Kobayashi, Kenichi
Yokoyama, Hitoshi
岩田, 恭宜
和田, 隆志
古市, 賢吾
北川, 清樹
坂井, 宣彦
清水, 美保
発行日: 2001年
出版社(者): The Japanese Society of Internal Medicine = 日本内科学会
雑誌名: Internal Medicine
ISSN: 1080-6040
巻: 40
号: 11
開始ページ: 1093
終了ページ: 1097
キーワード: Interstitial lung disease
Marker
Vascular disease
抄録: Objective. KL-6 is reported to be excreted from the lung alveolar and bronchial epithelial cells and may be a good marker for monitoring disease activity of interstitial pneumonia. This study was designed to ascertain the clinical significance of serum KL-6 levels in interstitial pneumonia associated with anti-neutrophil cytoplasmic antibody (ANCA)-related vasculitis. Methods. Serum KL-6 levels were determined by an enzyme-linked immunosorbent assay. Patients. We examined 20 healthy subjects, 13 patients with perinuclear (myeloperoxidase, MPO) ANCA-related vasculitis and 12 dermatomyositis (DM)/polymyositis (PM) patients as disease controls in this study. Six out of 13 patients with ANCA-related vasculitis had interstitial pneumonia. Results. Serum levels of KL-6 in ANCA-positive patients with interstitial pneumonia were significantly elevated, while they remained as low as those of healthy subjects in ANCA- positive patients without interstitial pneumonia. Similarly, KL-6 levels in sera were higher in 12 dermatomyositis/polymyositis patients with interstitial pneumonia, while they remained low in DM/PM patients without interstitial pneumonia. Moreover, the elevated serum KL-6 level was reduced during the convalescence induced by glucocorticoid therapy and reflected the disease activity of interstitial pneumonia associated with ANCA-related vasculitis. Conclusion. These data suggest that the measurement of serum KL-6 levels may be a good monitoring system for the diagnosis and follow-up of interstitial pneumonia of patients with ANCA-related vasculitis.
URI: http://hdl.handle.net/2297/25634
関連URI: http://ci.nii.ac.jp/naid/10007313731
http://www.naika.or.jp/
http://www.journalarchive.jst.go.jp/english/jnlabstract_en.php?cdjournal=internalmedicine1992&cdvol=40&noissue=11&startpage=1093
資料種別: Journal Article
権利関係: Copyright (c) 2001 by The Japanese Society of Internal Medicine
版表示: publisher
出現コレクション:1. 査読済論文(医学・保健)

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