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タイトル: Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity
著者: Katsuda, Hiromu
Yamashita, Mariko
Katsura, Hideyuki
Yu, Jia
Waki, Yoshihiro
Nagata, Naoto
Sai, Yoshimichi link image link image
Miyamoto, Kenichi link image
宮本, 謙一
発行日: 2010年
出版社(者): Pharmaceutical Society of Japan = 日本薬学会
雑誌名: Biological and Pharmaceutical Bulletin
ISSN: 0918-6158
巻: 53
号: 11
開始ページ: 1867
終了ページ: 1871
キーワード: Cimetidine
Reactive oxygen species
抄録: The present study examined the influence of cimetidine on the nephrotoxicity and antitumor effects of cisplatin in vitro and in vivo. When the serum concentration of cimetidine was maintained over 20 μg/ml for 4 h by bolus and continuous intravenous infusion, cimetidine prevented nephrotoxicity of cisplatin without influencing antitumor activity. Cimetidine and the antioxidant N-acetylcysteine (NAC) significantly inhibited the in vitro growth inhibition of cisplatin in cells originating from the kidney, but not in SOSN2 osteosarcoma cells. Cimetidine (1mM) also did not influence platinum concentration in the cells, regardless of whether the organic cation transporter 2 (OCT2) was expressed. Cisplatin did induce reactive oxygen species (ROS) in the KN41 kidney cell line and cimetidine and NAC significantly reduced ROS production. However, cisplatin did not produce ROS in osteosarcoma cells. From these results, cimetidine clearly inhibits nephrotoxicity induced by cisplatin without any influence on the antitumor activity of cisplatin on osteosarcoma in vitro and in vivo. © 2010 Pharmaceutical Society of Japan.
DOI: 10.1248/bpb.33.1867
URI: http://hdl.handle.net/2297/25781
関連URI: http://www.jstage.jst.go.jp/article/bpb/33/11/33_1867/_article
資料種別: Journal Article
権利関係: (c) 2010 The Pharmaceutical Society of Japan
版表示: publisher
出現コレクション:1. 査読済論文

このアイテムを引用あるいはリンクする場合は次の識別子を使用してください。 http://hdl.handle.net/2297/25781



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