DSpace width= university logo mark
Japanese | English 

KURA > C. 医薬保健学域・研究域/医・薬学部/医学系研究科 > c10. 学術雑誌掲載論文(医・保健) > 1. 査読済論文(医学・保健) >


ファイル 記述 サイズフォーマット
ME-PR-KOH-E-717.pdf6.41 MBAdobe PDF
タイトル: Human endogenous retrovirus K14C drove genomic diversification of the Y chromosome during primate evolution
著者: Shin, Ho-Su
Koh, Eitetsu link image
Kim, Dae-Soo
Murayama, Miho
Sugimoto, Kazuhiro
Maeda, Yuji link image
Yoshida, Atsumi
Namiki, Mikio link image
髙, 榮哲
前田, 雄司
並木, 幹夫
発行日: 2010年11月
出版社(者): The Japan Society of Human Genetics = 日本人類遺伝学会
雑誌名: Journal of Human Genetics
ISSN: 1434-5161
巻: 55
号: 11
開始ページ: 717
終了ページ: 725
キーワード: great ape
long terminal repeat
old world monkey
solitary LTR
testis-specific transcripts
抄録: The male-specific region of Y chromosome (MSY) has accumulated a higher density of human endogenous retroviruses (HERVs) and related sequences when compared with other regions of the human genome. Here, we focused on one HERV family, HERV-K14C that seemed to integrate preferentially into the Y chromosome in humans. To identify every copies of HERV-K14C in the human genome, we applied computational screening to map precisely the locus of individual HERV-K14C copies. Interestingly, 29 of all 146 copies were located in Y chromosome, and these 29 copies were mostly dispersed in the palindromic region. Three distinct HERV-K14C-related transcripts were found and were exclusively expressed in human testis tissue. Based on our phylogenetic analysis of the solitary LTRs derived from HERV-K14C on the Y chromosome we suggested that these sequences were generated as pairs of identical sequences. Specifically, analysis of HERV-K14C-related sequences in the palindromic region demonstrated that the Y chromosomal amplicons existed in our common ancestors and the duplicated pairs arose after divergence of great apes approximately 8-10 million years ago. Taken together, our observation suggested that HERV-K14C-related sequences contributed to genomic diversification of Y chromosome during speciation of great ape lineage. © 2010 The Japan Society of Human Genetics All rights reserved.
DOI: 10.1038/jhg.2010.94
URI: http://hdl.handle.net/2297/26247
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

このアイテムを引用あるいはリンクする場合は次の識別子を使用してください。 http://hdl.handle.net/2297/26247



Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - ご意見をお寄せください