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タイトル: Human endogenous retrovirus K14C drove genomic diversification of the Y chromosome during primate evolution
著者: Shin, Ho-Su
Koh, Eitetsu link image
Kim, Dae-Soo
Murayama, Miho
Sugimoto, Kazuhiro
Maeda, Yuji link image
Yoshida, Atsumi
Namiki, Mikio link image
髙, 榮哲
前田, 雄司
並木, 幹夫
発行日: 2010年11月
出版社(者): The Japan Society of Human Genetics = 日本人類遺伝学会
雑誌名: Journal of Human Genetics
ISSN: 1434-5161
巻: 55
号: 11
開始ページ: 717
終了ページ: 725
キーワード: great ape
hominoid
long terminal repeat
old world monkey
palindrome
solitary LTR
testis-specific transcripts
抄録: The male-specific region of Y chromosome (MSY) has accumulated a higher density of human endogenous retroviruses (HERVs) and related sequences when compared with other regions of the human genome. Here, we focused on one HERV family, HERV-K14C that seemed to integrate preferentially into the Y chromosome in humans. To identify every copies of HERV-K14C in the human genome, we applied computational screening to map precisely the locus of individual HERV-K14C copies. Interestingly, 29 of all 146 copies were located in Y chromosome, and these 29 copies were mostly dispersed in the palindromic region. Three distinct HERV-K14C-related transcripts were found and were exclusively expressed in human testis tissue. Based on our phylogenetic analysis of the solitary LTRs derived from HERV-K14C on the Y chromosome we suggested that these sequences were generated as pairs of identical sequences. Specifically, analysis of HERV-K14C-related sequences in the palindromic region demonstrated that the Y chromosomal amplicons existed in our common ancestors and the duplicated pairs arose after divergence of great apes approximately 8-10 million years ago. Taken together, our observation suggested that HERV-K14C-related sequences contributed to genomic diversification of Y chromosome during speciation of great ape lineage. © 2010 The Japan Society of Human Genetics All rights reserved.
DOI: 10.1038/jhg.2010.94
URI: http://hdl.handle.net/2297/26247
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

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