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タイトル: Airway wall structure assessed by endobronchial ultrasonography and bronchial hyperresponsiveness in patients with asthma
著者: Kita, Toshiyuki
Fujimura, Masaki link image
Sone, Takashi link image
Inuzuka, Kanako
Myou, Shigeharu link image
Nakao, Shinji link image link image
藤村, 政樹  
曽根, 崇
犬塚, 賀奈子
中尾, 眞二
発行日: 2010年10月
出版社(者): Lippincott Williams & Wilkins
雑誌名: Journal of Bronchology
ISSN: 1070-8030
巻: 17
号: 4
開始ページ: 301
終了ページ: 306
キーワード: Airway hyperresponsiveness
Airway remodeling
Endobronchial ultrasound
Mural structure
抄録: Background and Objective: The purpose of this study was to evaluate the relationship between the wall structure assessed by using endobronchial ultrasonography (EBUS) and bronchial hyperresponsiveness in patients with asthma. Methods: Twenty-four patients with stable asthma and 11 individuals without asthma were studied. EBUS was performed with a radial 20-MHz ultrasonic probe inserted into the intermediate bronchus undergoing flexible bronchoscopy to assess the airway wall structure. The percentage of airway wall thickness {WT%; defined as [(ideal outer diameter-ideal luminal diameter)/ideal outer diameter] × 100} was determined by EBUS. We measured bronchial hyperresponsiveness to methacholine [the provocative concentration of methacholine causing a decrease of 20% or more in forced expiratory volume in 1 s (PC20)]. Results: Percentage wall thickness measured by EBUS was significantly greater in patients with asthma than that in subjects without asthma (P < 0.01). The evaluation of the laminar structure using EBUS indicated that the thickness of the second layer in patients with asthma was greater than that in subjects without asthma (P < 0.05). PC20 was negatively correlated with the thickness of the second layer (r=0.52, P < 0.01) but was not significantly correlated with other layers in patients with asthma. Conclusions: The evaluation of the bronchial mural structure using EBUS might be advantageous for assessing the relationship between airway wall remodeling and bronchial hyperresponsiveness. © 2010 Lippincott Williams & Wilkins.
DOI: 10.1097/LBR.0b013e3181f9f09b
URI: http://hdl.handle.net/2297/26248
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

このアイテムを引用あるいはリンクする場合は次の識別子を使用してください。 http://hdl.handle.net/2297/26248



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