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タイトル: Airway wall structure assessed by endobronchial ultrasonography and bronchial hyperresponsiveness in patients with asthma
著者: Kita, Toshiyuki
Fujimura, Masaki link image
Sone, Takashi link image
Inuzuka, Kanako
Myou, Shigeharu link image
Nakao, Shinji link image link image
藤村, 政樹  
曽根, 崇
犬塚, 賀奈子
中尾, 眞二
発行日: 2010年10月
出版社(者): Lippincott Williams & Wilkins
雑誌名: Journal of Bronchology
ISSN: 1070-8030
巻: 17
号: 4
開始ページ: 301
終了ページ: 306
キーワード: Airway hyperresponsiveness
Airway remodeling
Asthma
Endobronchial ultrasound
Mural structure
抄録: Background and Objective: The purpose of this study was to evaluate the relationship between the wall structure assessed by using endobronchial ultrasonography (EBUS) and bronchial hyperresponsiveness in patients with asthma. Methods: Twenty-four patients with stable asthma and 11 individuals without asthma were studied. EBUS was performed with a radial 20-MHz ultrasonic probe inserted into the intermediate bronchus undergoing flexible bronchoscopy to assess the airway wall structure. The percentage of airway wall thickness {WT%; defined as [(ideal outer diameter-ideal luminal diameter)/ideal outer diameter] × 100} was determined by EBUS. We measured bronchial hyperresponsiveness to methacholine [the provocative concentration of methacholine causing a decrease of 20% or more in forced expiratory volume in 1 s (PC20)]. Results: Percentage wall thickness measured by EBUS was significantly greater in patients with asthma than that in subjects without asthma (P < 0.01). The evaluation of the laminar structure using EBUS indicated that the thickness of the second layer in patients with asthma was greater than that in subjects without asthma (P < 0.05). PC20 was negatively correlated with the thickness of the second layer (r=0.52, P < 0.01) but was not significantly correlated with other layers in patients with asthma. Conclusions: The evaluation of the bronchial mural structure using EBUS might be advantageous for assessing the relationship between airway wall remodeling and bronchial hyperresponsiveness. © 2010 Lippincott Williams & Wilkins.
DOI: 10.1097/LBR.0b013e3181f9f09b
URI: http://hdl.handle.net/2297/26248
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

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