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タイトル: Genetic diversity of HIV type 1 in Likasi, southeast of the Democratic Republic of Congo
著者: Kita, Kayoko
Ndembi, Nicaise
Ekwalanga, Michel
Ido, Eiji
Kazadi, Rigobert
Bikandou,  Blaise
Takehisa, Jun
Takemura, Taichiro
Kageyama, Seiji
Tanaka, Junji
Parra, Henri Joseph
Hayami, Masanori
Ichimura, Hiroshi link image link image
市村, 宏
発行日: 2004年12月
出版社(者): Mary Ann Liebert
雑誌名: AIDS Research and Human Retroviruses
ISSN: AA10689080
巻: 200
号: 12
開始ページ: 1352
終了ページ: 1357
抄録: To investigate the prevalence of subtypes A and C, and the existence of recombinants of both subtypes in the southeast of the Democratic Republic of Congo (DRC), blood samples were collected from 27 HIV-infected individuals in Likasi, located in an area bordering close to Zambia, and analyzed phylogenetically. Out of the 24 strains with a positive PCR profile for pol-IN and env-C2V3, 15 (62.5%) had a discordant subtype or CRF designation: one subtype A/G (pol/env), four A/U (unclassified), three G/A, one G/CRF01, three H/A, one J/C, one CRF02 (G)/A, and one U/A. Nine (37.5%) strains had a concordant subtype or CRF designation: five subtype A, two C, one D, and one CRF02/G. The remaining three samples negative for PCR with env-C2V3 primers used in this study were further analyzed with env-gp41 primers and revealed the presence of two profiles: two J/J (pol-IN/env-gp41) and one C/G. These data highlight the presence of a high proportion (16/27, 59.3%) of recombinant strains and a low prevalence (4.1 and 7.4%) of subtype C based on env-C2V3 and pol-IN analyses, respectively, in Likasi. In addition, this is the first report that CRF02_AG exists in DRC, though the epidemiological significance of the existence of CRF02_AG in DRC remains unknown.
URI: http://hdl.handle.net/2297/26537
資料種別: Journal Article
版表示: publisher
出現コレクション:1. 査読済論文(医学・保健)

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