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タイトル: Phagocytic removal of cells that have become unwanted: Implications for animal development and tissue homeostasis
著者: Nakanishi, Yoshinobu link image link image
Nagaosa, Kazushige
Shiratsuchi, Akiko link image link image
中西, 義信
永長, 一茂
発行日: 2011年 2月
出版社(者): Wiley-Blackwell / 日本発生生物学会 = Japanese Society of Developmental Biologists (JSDB)
雑誌名: Development Growth and Differentiation
ISSN: 0012-1592
巻: 53
号: 2
開始ページ: 149
終了ページ: 160
キーワード: Cell-cell recognition
Innate immunity
Morphogenesis
Phagocyte
Tissue homeostasis
抄録: Cells that have become unwanted need to be promptly, selectively, and safely removed. This is made possible by apoptosis-dependent phagocytosis, in which cells unnecessary, obstructive, or dangerous to organisms are induced to undergo apoptosis so that they are earmarked for phagocytosis. The phagocytic elimination occurs so quickly that cells with hallmarks of apoptosis are barely detectable in vivo. The removal of particular types of cells at appropriate stages of development not only contributes to the disposal of spent cells, the creation of space for morphogenesis, and the exclusion of pathogenic or noxious cells, but seems to actively control tissue renewal, tissue remodeling, tissue function, and pathogenic state. This event thus plays an indispensable role in the maintenance of animal development and tissue homeostasis. © 2011 The Authors. Journal compilation © 2011 Japanese Society of Developmental Biologists.
DOI: 10.1111/j.1440-169X.2010.01224.x
URI: http://hdl.handle.net/2297/27315
関連URI: http://www.jsdb.jp/
資料種別: Journal Article
版表示: author
出現コレクション:2.査読済論文(薬)

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