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タイトル: Monocyte chemoattractant protein-1 derived from biliary innate immunity contributes to hepatic fibrogenesis
著者: Harada, Kenichi link image link image
Chiba, Mayumi
Okamura, Atsushi
Hsu, Maylee
Sato, Yasunori link image link image
Igarashi, Saya
Ren, Xiang Shan
Ikeda, Hiroko link image link image
Ohta, Hajime
Kasashima, Satomi
Kawashima, Atsuhiro
Nakanuma, Yasuni link image
原田, 憲一
佐藤, 保則
五十嵐, 紗耶
池田, 博子
川島, 篤弘
中沼, 安二
発行日: 2011年 8月
出版社(者): BMJ Publishing Group
雑誌名: Journal of Clinical Pathology
ISSN: 0021-9746
巻: 64
号: 8
開始ページ: 660
終了ページ: 665
抄録: Aims: Monocyte chemoattractant protein-1 (MCP-1) is a major chemotactic factor for hepatic stellate cells (HSCs) associated with hepatic fibrosis. In this study, among several fibrogenetic factors derived from biliary epithelial cells (BECs), MCP-1 produced by the biliary innate immune system was found to be most critical in the histogenesis of hepatic fibrogenesis. Methods: Using cultured human BECs, the expression of five fibrogenetic factors including MCP-1 on stimulation with Toll-like receptor ligands, inflammatory cytokines or bile acids was examined. Moreover, in situ detection of MCP-1 and α-smooth muscle actin proteins was performed using sections from normal and diseased livers by immunohistochemistry. Results: All fibrogenetic factors were detected in BECs, but only MCP-1 expression was upregulated, by all the Toll-like receptor ligands, IL-1β, and tumour necrosis factor-alpha. Proliferating bile ductules in interface areas expressed MCP-1 in diseased livers accompanying α-smooth muscle actin-positive activated HSCs. Conclusions: Bile ductules proliferate in various hepatobiliary diseases, and its significance is still unknown. This study demonstrated that BECs in bile ductules could produce MCP-1, particularly, via biliary innate immunity, suggesting that MCP-1 derived from BECs plays an important role in the recruitment of HSCs to interface areas and the activation of HSCs resulting in the progression of periportal fibrosis. Copyright Article author (or their employer) 2011.
DOI: 10.1136/jclinpath-2011-200040
URI: http://hdl.handle.net/2297/27835
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

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