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タイトル: Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection
著者: Yamashita, Taro link image link image
Honda, Masao link image link image
Kaneko, Shuichi link image link image
山下, 太郎
本多, 政夫
金子, 周一
発行日: 2011年 6月
出版社(者): Blackwell Publishing Asia Pty
雑誌名: Journal of Gastroenterology and Hepatology
ISSN: 0815-9319
巻: 26
号: 6
開始ページ: 960
終了ページ: 964
キーワード: Hepatitis C virus
Hepatocellular carcinoma
抄録: Hepatitis C virus (HCV) infection is a major cause of hepatocellular carcinoma (HCC) and chronic liver disease worldwide. Recent developments and advances in HCV replication systems in vitro and in vivo, transgenic animal models, and gene expression profiling approaches have provided novel insights into the mechanisms of HCV replication. They have also helped elucidate host cellular responses, including activated/inactivated signaling pathways, and the relationship between innate immune responses by HCV infection and host genetic traits. However, the mechanisms of hepatocyte malignant transformation induced by HCV infection are still largely unclear, most likely due to the heterogeneity of molecular paths leading to HCC development in each individual. In this review, we summarize recent advances in knowledge about the mechanisms of hepatocarcinogenesis induced by HCV infection. © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
DOI: 10.1111/j.1440-1746.2011.06723.x
URI: http://hdl.handle.net/2297/28344
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

このアイテムを引用あるいはリンクする場合は次の識別子を使用してください。 http://hdl.handle.net/2297/28344



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