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タイトル: Oxidative Stress Correlates with Left Ventricular Volume after Acute Myocardial Infarction
著者: Fujii, Hiroyuki
Shimizu, Masami
Ino, Hidekazu
Yamaguchi, Masato
Terai, Hidenobu
Mabuchi, Hiroshi
Michishita, Ichiro
Genda, Akira
清水, 賢巳
井野, 秀一
馬渕, 宏
発行日: 2002年
出版社(者): Japanese Heart Journal Assciation
雑誌名: Japanese Heart Journal
ISSN: 0021-4868
巻: 43
号: 3
開始ページ: 203
終了ページ: 209
キーワード: Left ventricular remodeling
Lipoproteins
Myocardial infarction
Oxidative stress
抄録: It has been suggested that oxidative stress may play a role in the pathophysiology of heart failure. However, little is known about the clinical relationship between oxidative stress and left ventricular dilatation after acute myocardial infarction (AMI). We prospectively studied 28 consecutive patients, successfully treated with primary coronary angioplasty, after their first AMI. To evaluate oxidative stress, plasma oxidized low-density LDL levels (U/mL) were measured serially 1 day, 7 days, 14 days, 30 days, and 90 days after the onset of AMI using a specific sandwich enzyme-linked immunosorbent assay. Left ventriculography and coronary angiography were obtained in all patients 3 months after the AMI and infarct-related arteries were all patent. Peak plasma oxidized LDL levels were seen 7 days after AMI (after 1 day: 14.71.5, 7 days: 21.02.8, 14 days: 20.22.8, 30 days: 18.32.5, 90 days: 16.52.3 U/mL). Plasma oxidized LDL levels 7 days after AMI were significantly correlated with left ventricular end-diastolic volume (1157 mL; r=0.54, P=0.0025) and end-systolic volume (585 mL; r=0.49, P=0.008) 3 months after the AMI. Moreover, they were also correlated with end-diastolic volume index (684 mL/m2, r=0.40, P<0.05). However, no correlation was seen between peak plasma oxidized LDL levels and ejection fraction. These findings suggest that oxidative stress may play an important role in the development and progression of left ventricular remodeling after AMI.
URI: http://hdl.handle.net/2297/28407
関連URI: http://www.jstage.jst.go.jp/article/jhj/43/3/43_203/_article/-char/ja/
http://ci.nii.ac.jp/naid/30010197304
http://square.umin.ac.jp/jhj/
資料種別: Journal Article
権利関係: Copyright (c) 2002 by the Japanese Heart Journal
版表示: publisher
出現コレクション:1. 査読済論文

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