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タイトル: 乳がん化学療法における爪に対する副作用の実態調査
その他のタイトル: Investigation of Adverse Drug Events in Nails during Breast Cancer Chemotherapy
著者: 竹下, 英里
橋本, 秀子
石本, 聖
河原, 昌美
橋本, 政和
宮本, 謙一 link image
Takeshita, Eri
Hashmoto, Hideko
Ishimoto, Takashi
Kawahara, Masami
Hashimoto, Masakazu
Miyamoto, Kenichi
発行日: 2008年 1月10日
出版社(者): 日本医療薬学会 = Japanese Society of Phamaceutical Health care and Sciences
雑誌名: 医療薬学
ISSN: 1346-342X
巻: 34
号: 1
開始ページ: 79
終了ページ: 84
キーワード: breeast cancer chemotherapy
fluorouracil
epirubicin
cyclophosphamide
docetaxel
nail discoloration
抄録: Epirubicin-cyclophosphamide (EC) and fluorouracil-epirubicin-cyclophosphamide (FEC),2 epirubicin-based regimens,are often switched to docetaxel (DOC) in chemotherapy before and after breast surgery.As nail discoloration had been frequently observed during these breast cancer chemotherapy regimens,we investigated adverse drug events in nails.Drug adverse events were observed in the nails of 87% of patients treated with EC,in 83% treated with FEC,and 58% treated with DOC following the switch from EC or FEC.With regard to the time of onset,most nail discoloration appeared after second or third course of chemotherapy with EC or FEC.Adverse drug events differed depending on the chemotherapy regimen.Nail discoloration was nearly all specific to EC and FEC and nail bed pain,onycholysis,and koilonychias tended to occur with DOC.Though most adverse drug events in the nails were mild,any of Grade 2 (CTCAE v 3.0) occurring would have impaired quality of life and caused psychological stress.Therefore,pharmacists should inform patients receiving these chemotherapies of the possibility of adverse drug events in the nails and observe them carefully.They should also recommend consultation with a dermatologist as early as possible if Grade 2 adverse drug events should occur.
DOI: 10.5649/jjphcs.34.79
URI: http://hdl.handle.net/2297/28422
関連URI: http://www.jsphcs.jp/
http://ci.nii.ac.jp/naid/110006546904
JST.JSTAGE/jjphcs/34.79
資料種別: Journal Article
権利関係: Copyright (c) 2009 日本医療薬学会
版表示: publisher
出現コレクション:1. 査読済論文

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