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タイトル: Effects of Ketamine and Propofol on the Ratio of Interleukin-6 to Interleukin-10 during Endotoxemia in Rats
著者: Taniguchi, Takumi link image link image
Kanakura, Hiroko
Takemoto, Yasuhiro
Kidani, Yoko
Yamamoto, Ken link image
谷口, 巧
山本, 健
発行日: 2003年 6月 1日
出版社(者): 東北ジャーナル刊行会
雑誌名: Tohoku journal of experimental medicine
ISSN: 0040-8727
巻: 200
号: 2
開始ページ: 85
終了ページ: 92
キーワード: cytokine response
ketamine
lipopolysaccharide
propofol
sepsis
抄録: Our previous study reported that the change in the ratio of interleukin (IL)-6 to IL-10 influences the severity of sepsis in patients with systemic inflammatory response syndrome. We evaluated the change in the ratio of IL-6 to IL-10 after administration of ketamine or propofol in endotoxin-exposed rats in order to evaluate the relationship of pro-inflammatory and anti-inflammatory cytokines following ketamine or propofol administration during endotoxemia. We randomly assigned 40 rats to one of four equal groups: endotoxin alone, receiving Escherichia coli endotoxin (15 mg-/kg, i.v.); saline control; ketamine (10 mg·kg−1·h−1, i.v.) before and during exposure to endotoxin; and propofol (10 mg·kg−1·h−1, i.v.) before and during exposure to endotoxin. We measured the plasma concentrations of tumor necrosis factor (TNF)-α, IL-6, and IL-10 and calculated the ratio of IL-6 to IL-10 in each group. The current study showed that ketamine and propofol administration attenuated the increase in TNF-α, IL-6, and IL-10, and ketamine attenuated the increase in the ratio of IL-6 to IL-10, but propofol increased this ratio in rats receiving a single intravenous bolus of endotoxin. While the mechanisms responsible for the inhibitory effects require further investigation, our results suggest that proper use of ketamine as an anesthetic agent may offer certain advantages in the management of patients with endotoxemia.
DOI: 10.1620/tjem.200.85
URI: http://hdl.handle.net/2297/28481
関連URI: http://www.journal.med.tohoku.ac.jp/
http://ci.nii.ac.jp/naid/50000281335
JST.JSTAGE/tjem/200.85
資料種別: Journal Article
権利関係: Copyright (c) 2004 Tohoku University Medical Press
版表示: publisher
出現コレクション:1. 査読済論文(医学・保健)

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