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タイトル: Involvement of NGF in the Rat Model of Persistent Muscle Pain Associated With Taut Band
著者: Li, Jun
Yi, Shuang-Qin
Wang, Heng-Xiao
Yi, Nozomi
Ogawa, Yuki
Ozaki, Noriyuki link image link image
Itoh, Masahiro
易, 勤
尾﨑, 紀之
発行日: 2011年10月
出版社(者): Churchill Livingstone / American Pain Society
雑誌名: Journal of Pain
ISSN: 1526-5900
巻: 12
号: 10
開始ページ: 1059
終了ページ: 1068
キーワード: mechanical hyperalgesia
Muscle pain
myofascial pain syndrome
nerve growth factor
taut band
trigger point
抄録: Myofascial pain syndrome (MPS) is an important clinical condition characterized by chronic muscle pain and a myofascial trigger point (MTrP) located in a taut band (TB). However, its pathogenic mechanism is still unclear. We developed an animal model relevant to conditions of MPS, and analyzed the mechanism of the muscle pain in this model. We applied eccentric contraction (EC) to a rat's gastrocnemius muscle (GM) for 2 weeks, and examined the mechanical withdrawal thresholds, histological changes, and expressions and contents of nerve growth factor (NGF). The mechanical withdrawal threshold decreased significantly at the next day of first EC and continued up to 9 days after EC. TBs were palpable at 3 to 8 days after initiation of EC. In EC animals, necrotic and regenerating muscle cells were found significantly more than in control animals. In EC animals, NGF expressions in regenerating muscle cells and NGF contents of GM were significantly higher than control animals. Administration of NGF receptor (TrkA) inhibitor K252a showed significant suppression of mechanical hyperalgesia in EC animals. Repeated EC induced persistent mechanical muscle hyperalgesia associated with TB. NGF expressed in regenerating muscle cells may have an important role in persistent mechanical muscle hyperalgesia which might be relevant to pathogenesis of MPS. Perspective: The present study shows that NGF expressed in regenerating muscle cells is involved in persistent muscular mechanical hyperalgesia. NGF-TrkA signaling in primary muscle afferent neurons may be one of the most important and promising targets for MPS. © 2011 American Pain Society.
DOI: 10.1016/j.jpain.2011.04.010
URI: http://hdl.handle.net/2297/28500
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

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