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タイトル: Cryoimmunology for malignant bone and soft-tissue tumors
著者: Nishida, Hideji
Yamamoto, Norio link image link image
Tanzawa, Yoshikazu
Tsuchiya, Hiroyuki link image link image
西田, 英司
山本, 憲男
丹澤, 義一
土屋, 弘行
発行日: 2011年 4月
出版社(者): Springer Verlag (Germany)
雑誌名: International Journal of Clinical Oncology
ISSN: 1341-9625
巻: 16
号: 2
開始ページ: 109
終了ページ: 117
キーワード: Bone and soft-tissue sarcoma
Cryoimmunology
Cryotreatment
Immunotherapy
抄録: Several new methods have recently been developed for the treatment of malignant bone and soft-tissue tumors, and many of these targeted therapies have yielded promising initial results in clinical settings. As more sarcomas become amenable to effective molecular-targeting therapy, the need to evaluate the synergistic effects of combination therapies with anticancer drugs will grow. Other immunologic therapies have also been reported, such as exogenous cytokines, dendritic cell (DC) therapy and peptide vaccines. Cryoimmunology has shown promising results in some malignant tumors after cryosurgery and is expected to influence the next generation of tumor immunotherapy. In this report, we describe the induction of a systemic antitumor immune response following liquid nitrogen cryotreatment of a destructive murine osteosarcoma. Combining tumor cryotreatment with DCs to promote tumor-specific immune responses enhanced systemic immune responses and inhibited metastatic tumor growth. We also describe the induction of a systemic antitumor immune response following reconstruction for malignant bone tumors using frozen autografts treated with liquid nitrogen. © Japan Society of Clinical Oncology 2011.
DOI: 10.1007/s10147-011-0218-2
URI: http://hdl.handle.net/2297/28502
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文

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