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タイトル: Destruction of pancreatic β-cells by transgenic induction of prostaglandin e2 in the islets
著者: Oshima, Hiroko link image link image
Taketo, Makoto Mark
Oshima, Masanobu link image link image
大島, 浩子
大島, 正伸
発行日: 2006年 9月
出版社(者): American Society of Biochemistry and Molecular Biology
American Society for Biochemistry and Molecular Biology
引用: Journal of Biological Chemistry,281(39),pp.29330-29336
雑誌名: Journal of Biological Chemistry
ISSN: 0021-9258
巻: 281
号: 39
開始ページ: 29330
終了ページ: 29336
抄録: Type 2 diabetes mellitus is characterized by insulin resistance of peripheral tissues and dysfunction of pancreatic β-cells. Furthermore, the number of pancreatic β-cells decreases as a secondary effect of advanced type 2 diabetes, although the molecular mechanism has not been elucidated. Recently, it has been shown that hyperglycemic conditions induce the expression of cyclooxygenase-2 in pancreatic islets and increase the downstream product prostaglandin E2 (PGE2). To investigate whether high glucose-induced PGE2 has an adverse effect on pancreatic β-cells, we generated transgenic mice (RIP-C2mE) that express cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in their β-cells using the rat insulin-2 gene promoter (RIP). The homozygous RIP-C2mE (Tg/Tg) mice showed severe hyperglycemia from six weeks of age. Although the heterozygous RIP-C2mE (Tg/-) mice showed normal blood glucose levels throughout their lifetime, this level increased significantly compared with that of wild-type mice when glucose was loaded. The relative number of β-cells to the total islet cell number was reduced to 54 and 14% in the RIP-C2mE (Tg/-) and (Tg/Tg) mice, respectively, whereas that in the wild-type mice was 84%. Importantly, the proliferation rate in the islets of the RIP-C2mE (Tg/Tg) mice at four weeks of age decreased significantly in comparison to that in the wild-type mice. Because β-cells replicate not only during the postnatal period but also in the adult pancreas at a basal level, it is possible that increased PGE2 signaling thus contributes to the reduction of the pancreatic β-cell mass through inhibition of proliferation, thereby aggravating diabetes further. © 2006 by The American Society for Biochemistry and Molecular Biology, Inc.
URI: http://hdl.handle.net/2297/2851
関連URI: http://dx.doi.org/10.1074/jbc.M602424200
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文

このアイテムを引用あるいはリンクする場合は次の識別子を使用してください。 http://hdl.handle.net/2297/2851



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