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タイトル: Destruction of pancreatic β-cells by transgenic induction of prostaglandin e2 in the islets
著者: Oshima, Hiroko link image link image
Taketo, Makoto Mark
Oshima, Masanobu link image link image
大島, 浩子
大島, 正伸
発行日: 2006年 9月
出版社(者): American Society of Biochemistry and Molecular Biology
American Society for Biochemistry and Molecular Biology
引用: Journal of Biological Chemistry,281(39),pp.29330-29336
雑誌名: Journal of Biological Chemistry
ISSN: 0021-9258
巻: 281
号: 39
開始ページ: 29330
終了ページ: 29336
抄録: Type 2 diabetes mellitus is characterized by insulin resistance of peripheral tissues and dysfunction of pancreatic β-cells. Furthermore, the number of pancreatic β-cells decreases as a secondary effect of advanced type 2 diabetes, although the molecular mechanism has not been elucidated. Recently, it has been shown that hyperglycemic conditions induce the expression of cyclooxygenase-2 in pancreatic islets and increase the downstream product prostaglandin E2 (PGE2). To investigate whether high glucose-induced PGE2 has an adverse effect on pancreatic β-cells, we generated transgenic mice (RIP-C2mE) that express cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in their β-cells using the rat insulin-2 gene promoter (RIP). The homozygous RIP-C2mE (Tg/Tg) mice showed severe hyperglycemia from six weeks of age. Although the heterozygous RIP-C2mE (Tg/-) mice showed normal blood glucose levels throughout their lifetime, this level increased significantly compared with that of wild-type mice when glucose was loaded. The relative number of β-cells to the total islet cell number was reduced to 54 and 14% in the RIP-C2mE (Tg/-) and (Tg/Tg) mice, respectively, whereas that in the wild-type mice was 84%. Importantly, the proliferation rate in the islets of the RIP-C2mE (Tg/Tg) mice at four weeks of age decreased significantly in comparison to that in the wild-type mice. Because β-cells replicate not only during the postnatal period but also in the adult pancreas at a basal level, it is possible that increased PGE2 signaling thus contributes to the reduction of the pancreatic β-cell mass through inhibition of proliferation, thereby aggravating diabetes further. © 2006 by The American Society for Biochemistry and Molecular Biology, Inc.
URI: http://hdl.handle.net/2297/2851
関連URI: http://dx.doi.org/10.1074/jbc.M602424200
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文

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