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タイトル: TAK-603, an anti-inflammatory compound, reduces crescentic glomerulonephritis and preserves renal function in WKY rats
著者: Yamahana, Junya
Wada, Takashi link image link image
Yokoyama, Hitoshi link image
Kaneko, Shuichi link image link image
Furuichi, Kengo link image link image
和田, 隆志
古市, 賢吾
金子, 周一
発行日: 2006年10月
出版社(者): Oxford University Press
引用: Nephrology Dialysis Transplantation,21(10),pp.2736-2744
雑誌名: Nephrology Dialysis Transplantation
ISSN: 0931-0509
http://dx.doi.org/10.1093/ndt/gfl431
巻: 21
号: 10
開始ページ: 2736
終了ページ: 2744
キーワード: Crescentic glomerulonephritis
Th1/Th2
WKY rats
抄録: Background. The therapeutic efficacy of the regulation of T helper (Th)-1-predominant immune responses remains to be investigated. Therefore, the effects of the anti-inflammatory compound TAK-603 were investigated in a model of crescentic glomerulonephritis induced by a small dose of nephrotoxic serum in Wistar-Kyoto rats. Methods. TAK-603 (50 mg/kg body weight) was administered orally, starting at the time of induction of glomerulonephritis. In group 1, the drug was administered daily for the initial 6 days. TAK-603 was administered on day 0 only in group 2, and from day 3 to 5 in group 3. In each group, nephritic rats were killed on days 6 and 56. Results. In group 1 consisting of rats treated with TAK-603 daily from day 0 to 5, glomerular damage, including crescent formation, was improved on day 6, with reductions in the numbers of CD4, CD8 and ED-1 positive cells, as well as in urinary protein excretion. Protein and transcript levels of Th1 cytokines in the diseased kidneys were markedly decreased by TAK-603 treatment. Renal pathology, including glomerulosclerosis and interstitial fibrosis, was ameliorated and proteinuria was markedly decreased. Elevated levels of serum creatinine showed concomitant improvement. In group 3, in which treatment was initiated shortly after the appearance of glomerular abnormalities, glomerular damage was also diminished, resulting in a decrease in urinary protein excretion. Treatment only on the first day in group 2, partially rescued renal dysfunction. Conclusions. These results suggest the possible therapeutic application of inhibition of Th1-predominant immune responses in progressive crescentic glomerulosclerosis. © 2006 Oxford University Press.
URI: http://hdl.handle.net/2297/2862
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文

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