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タイトル: Differential expression of CD45RO (UCHL1) and its functional relevance in two subpopulations of circulating TCR-γ/δ+ lymphocytes
著者: Miyawaki, Toshio
Kasahara, Yoshito
Taga, Kazuyuki
Yachie, Akihiro link image link image
Taniguchi, Noboru
宮脇, 利男
笠原, 善仁
谷内江, 昭宏
谷口, 昂
発行日: 1990年
出版社(者): Rockefeller University Press
雑誌名: Journal of Experimental Medicine
ISSN: 0022-1007
巻: 171
号: 5
開始ページ: 1833
終了ページ: 1838
抄録: We examined the developmental profile of TCR-γ/δ+ cells with respect to CD45RO expression. Although total TCR-γ/δ+ cells were negligible in the neonatal blood and increased with advancing age, most blood TCR-γ/δ+ cells markedly expressed CD45RO without a distinction of age, probably reflecting a different CD45RO expression of two subsets defined by BB3 and δTCS1 mAbs. The vast majority of BB3+ cells expressed CD45RO, whereas expression of CD45RO was virtually absent in the δTCS1+ population. Functional studies revealed that, while both TCR-γ/δ+ cell subsets showed CD3-mediated activation, only BB3+ (or TiγA+) cells, but not δTCS1+ cells, appeared to proliferate in response to PPD in PPD-reactive individuals. The results suggested that the CD45RO+ (BB3+ or TiγA+) subset among blood TCR-γ/δ+ cells may be mainly involved in the memory or primed component of the immune system responding to some foreign antigens.
DOI: 10.1084/jem.171.5.1833
URI: http://hdl.handle.net/2297/29240
関連URI: http://jem.rupress.org/content/171/5/1833
資料種別: Journal Article
権利関係: © 1990 Rockefeller University Press
版表示: publisher
出現コレクション:1. 査読済論文(医学・保健)

このアイテムを引用あるいはリンクする場合は次の識別子を使用してください。 http://hdl.handle.net/2297/29240



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