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タイトル: Erythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy
著者: Ando, Hitoshi
Takamura, Toshinari link image link image
Nagai, Yukihiro
Kaneko, Shuichi link image link image
安藤, 仁
篁, 俊成
金子, 周一
発行日: 2006年11月
出版社(者): Elsevier BV
引用: Journal of Diabetes and its Complications,20(6),pp367-370
雑誌名: Journal of Diabetes and its Complications
ISSN: 1056-8727
号: 6
開始ページ: 367
終了ページ: 370
抄録: The relationship between the effect of aldose reductase inhibitors (ARIs) on the activation of the polyol pathway and on diabetic neuropathy has not been fully established. To address this issue, we investigated the effect of epalrestat (150 mg/day), an ARI, on erythrocyte sorbitol levels as an index of polyol activation and on nerve function test results in 43 patients with diabetic peripheral polyneuropathy. After 6 months of epalrestat administration, erythrocyte sorbitol levels did not decrease in patients as a whole. However, a decrease in erythrocyte sorbitol levels during epalrestat administration was significantly correlated with baseline erythrocyte sorbitol levels (ρ=-.47, P<.01): The higher the level at baseline, the greater the decrease after epalrestat treatment. Moreover, the mean sorbitol level during epalrestat treatment was associated with the beneficial effect of epalrestat on vibration sensitivity as measured with a C-128 tuning fork (ρ=-.66, P<.01) and/or a pallesthesiometer TM-31A (ρ=.53, P<.05). On the other hand, erythrocyte sorbitol levels did not reflect the prognosis of nerve conduction velocity. These findings at least partly suggest a causal relationship between polyol activation and the development of diabetic neuropathy. Aldose reductase inhibitor treatment may be clinically useful in the control of polyol activation, especially in patients with excessive accumulation of sorbitol. © 2006 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/2297/3031
関連URI: http://dx.doi.org/10.1016/j.jdiacomp.2005.09.002
http://www.elsevier.com/locate/issn/10568727
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文

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