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タイトル: Roles of DRB1*1501 and DRB1*1502 in the pathogenesis of aplastic anemia
著者: Sugimori, Chiharu
Yamazaki, Hirohito link image link image
Feng, Xingmin
Mochizuki, Kanako
Kondo, Yukio link image link image
Takami, Akiyoshi link image
Chuhjo, Tatsuya
Kimura, Akinori
Teramura, Masanao
Mizoguchi, Hideaki
Omine, Mitsuhiro
Nakao, Shinji link image link image
杉盛, 千春
山﨑, 宏人
望月, 果奈子
近藤, 恭夫
高見, 昭良
中尾, 眞二
発行日: 2007年 1月
出版社(者): Elsevier BV
引用: Experimental Hematology 35(1),pp. 13-20
雑誌名: Experimental Hematology
ISSN: 0301-472X
巻: 35
号: 1
開始ページ: 13
終了ページ: 20
抄録: Objective: Although a number of reports have documented a significantly increased incidence of HLA-DR15 in aplastic anemia (AA), the exact role of HLA-DR15 in the immune mechanisms of AA remains unclear. We herein clarify the difference between DRB1*1501 and DRB1*1502, the two DRB1 alleles that determine the presentation of HLA-DR15, in the pathophysiology of AA. Materials and Methods: We investigated the relationships of the patients* HLA-DRB1 allele with both the presence of a small population of CD55-CD59- (PNH-type) blood cells and the response to antithymocyte globulin (ATG) plus cyclosporin (CsA) therapy in 140 Japanese AA patients. Results: Of the 30 different DRB1 alleles, only DRB1*1501 (33.6% vs 12.8%, pc < 0.01) and DRB1*1502 (43.6% vs 24.4%, pc < 0.01) displayed significantly higher frequencies among the AA patients than among a control. AA patients possessing HLA-DR15 tended to be old, and especially, the frequency of DRB1*1502 in patients 40 years of age and older (52.4%) was markedly higher than that in those younger than 40 years old (16.2%, pc < 0.01). Only DRB1*1501 was significantly associated with the presence of a small population of PNH-type cells and it also showed a good response to ATG plus CsA therapy in a univariate analysis. A multivariate analysis showed only the presence of a small population of PNH-type cells to be a significant factor associated with a good response to the immunosuppressive therapy (p < 0.01). Conclusions: Although both DRB1*1501 and DRB1*1502 contribute to the development of AA, the methods of contribution differ between the two alleles. © 2007 International Society for Experimental Hematology.
URI: http://hdl.handle.net/2297/3448
関連URI: http://dx.doi.org/10.1016/j.exphem.2006.09.002
http://www.elsevier.com/locate/issn/0301472X
資料種別: Journal Article
出現コレクション:1. 査読済論文

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