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タイトル: Anti-inflammatory effects of lipoic acid through inhibition of GSK-3β in lipopolysaccharide-induced BV-2 microglial cells
著者: Koriyama, Yoshiki link image
Nakayama, Yuya
Matsugo, Seiichi link image link image
Sugitani, Kayo link image link image
Ogai, Kazuhiro
Takadera, Tsuneo link image link image
Kato, Satoru link image
郡山, 恵樹
松郷, 誠一
杉谷, 加代
大貝, 和裕
加藤, 聖
発行日: 2013年 9月
出版社(者): Elsevier
雑誌名: Neuroscience Research
ISSN: 0168-0102
巻: 77
号: 1-2
開始ページ: 87
終了ページ: 96
キーワード: Akt
GSK-3β
Inflammation
Lipoic acid
Microglia
NF-κB
抄録: Activated microglial cells play an important role in immune and inflammatory responses in CNS and play a role in neurodegenerative diseases. We examined the effects of lipoic acid (LA) on inflammatory responses of BV-2 microglial cells activated by lipopolysaccharide (LPS), and explored the underlying mechanisms of action of LA. BV-2 cells treated with LPS showed an up-regulation of mRNA of the pro-inflammatory molecules, inducible nitric oxide synthase (iNOS). LA suppressed the expression of iNOS and furthermore, LPS-induced production of nitrite. Moreover, LA suppressed the nuclear translocation of RelA, a component of nuclear factor-kappa B (NF-κB) that contains transcriptional activator domain for LPS. The mechanisms of LA-mediated anti-inflammatory effects on microglia remain unknown, and we suggested an involvement of Akt/glycogen synthase kinase-3β (GSK-3β) phosphorylation. The results showed that inhibitor of phosphatidylinositol 3-kinase prevented LA-mediated suppression of LPS induction of RelA and expression of iNOS. Furthermore, these inflammatory actions were prevented by GSK-3β inhibitors. These data demonstrate a role for LA as a chemical modulator of inflammatory responses by microglia, and thus may be a therapeutic strategy for treating neurodegenerative diseases with an inflammatory component. © 2013 Elsevier Ireland Ltd and the Japan Neuroscience Society.
DOI: 10.1016/j.neures.2013.07.001
URI: http://hdl.handle.net/2297/36255
関連URI: http://www.elsevier.com/locate/issn/01680102
資料種別: Journal Article
版表示: author
出現コレクション:2.査読済論文(薬)

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