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タイトル: Regulation of N-cadherin-based cell–cell interaction by JSAP1
著者: Bayarsaikhan, Munkhuu
Takino, Takahisa link image link image
Gantulga, Davaakhuu
Yoshioka, Katsuji link image link image
Sato, Hiroshi link image
滝野, 隆久
佐藤, 博
善岡, 克次
発行日: 2007年 2月 9日
出版社(者): Elsevier
引用: Biochemical and Biophysical Research Communications 353(2) ,pp. 357-362
雑誌名: Biochemical and Biophysical Research Communications 
ISSN: 0006-291X
巻: 353
号: 2
開始ページ: 357
終了ページ: 362
キーワード: Cadherin
Differentiation
JNK
MAP kinase
NGF
RNA interference
Scaffold protein
抄録: We previously reported that the level of c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1), a scaffold protein for JNK signaling, increases dramatically during nerve growth factor (NGF)-induced differentiation of PC12h cells. In the present study, we investigated the function of JSAP1 during PC12h cell differentiation by knocking down the level of JSAP1. The depletion of JSAP1 caused NGF-treated PC12h cells to form aggregates and impaired their differentiation. The aggregation was not observed in JSAP1-depleted cells that were untreated or treated with epidermal growth factor. Immunocytochemical studies indicated that N-cadherin, but not E-cadherin, was localized to sites of cell–cell contact in the aggregated cells. Furthermore, an inhibitory anti-N-cadherin antibody completely blocked the aggregation. Taken together, these results suggest that JSAP1 regulates cell–cell interactions in PC12h cells specifically in the NGF-induced signaling pathway, and does so by modulating N-cadherin.
URI: http://hdl.handle.net/2297/3640
関連URI: http://dx.doi.org/10.1016/j.bbrc.2006.12.029
http://www.sciencedirect.com/science/journal/0006291X
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文

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