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タイトル: B cell signaling and autoimmune diseases: CD19/CD22 loop as a B cell signaling device to regulate the balance of autoimmunity
著者: Fujimoto, Manabu
Sato, Shinichi
藤本, 学
発行日: 2007年 4月
出版社(者): Elsevier BV
引用: Journal of Dermatological Science 46(1), pp.1-9
雑誌名: Journal of Dermatological Science
ISSN: 0923-1811
巻: 46
号: 1
開始ページ: 1
終了ページ: 9
キーワード: Autoimmunity
CD19
CD22
Systemic sclerosis
Tight-skin mouse
抄録: Autoimmune diseases, including connective tissue diseases and bullous diseases, may be life-threatening. Recent clinical and experimental approaches have demonstrated that B cells play critical roles in the manifestation of autoimmune disease not only by well-established autoantibody-mediated mechanisms but also by a variety of other functions. These B cell functions are under the regulation of B cell antigen receptor (BCR)-induced signals and by specialized cell surface coreceptors, or "response regulators", which inform B cells of their microenvironment. These response regulators include CD19 and CD22. CD19 and CD22 do not merely regulate BCR signals independently, but they have their own regulatory network. CD19 regulates CD22 phoshorylation by augmenting Lyn kinase activity, while CD22 inhibits CD19 phosphorylation via SHP-1. Importantly, this "CD19/CD22 loop" is significantly related to an autoimmune phenotype in mice. Thus, the CD19/CD22 loop may be a potential therapeutic target in autoimmune disease for modulating B cell signaling. © 2006 Japanese Society for Investigative Dermatology.
URI: http://hdl.handle.net/2297/3661
関連URI: http://dx.doi.org/10.1016/j.jdermsci.2006.12.004
http://www.elsevier.com/locate/issn/09231811
資料種別: Journal Article
出現コレクション:1. 査読済論文(医学・保健)

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