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タイトル: Effects of T-tubules on dielectric spectra of skeletal muscle simulated by boundary element method with two-dimensional models
著者: Sekine, Katsuhisa link image link image
Hibino, Chiharu
Kimura, Miyuki
Asami, Koji
関根, 克尚
発行日: 2007年 5月
出版社(者): Elsevier
引用: Bioelectrochemistry 70(2), pp. 532-541
雑誌名: Bioelectrochemistry
ISSN: 1567-5394
巻: 70
号: 2
開始ページ: 532
終了ページ: 541
キーワード: Boundary element method
Complex permittivity
Dielectric relaxation
Interfacial polarization
Muscle cell
T-tubule
抄録: In order to investigate the origin of large intensity the α-relaxation in skeletal muscles observed in dielectric measurements with extracellular electrode methods, effects of the interfacial polarization in the T-tubules on dielectric spectra were evaluated with the boundary-element method using two-dimensional models in which the structure of the T-tubules were represented explicitly. Each model consisted of a circular inclusion surrounded by a thin shell corresponding to the sarcolemma. The T-tubules were represented by simplified two types of invagination of the shell: straight invagination along the radial directions, and branched one. Each of the models was subjected to two kinds of calculations relevant to experiments with the extracellular and the intracellular electrode methods. Electrical interactions between the cells were omitted in the calculations. Both calculations showed that the dielectric spectra of the models contained two relaxation terms. The low-frequency relaxation term assigned to the α-relaxation depended on the structure of the T-tubules. Values of the relaxation frequency of the α-relaxation obtained from the two types of calculations agreed with each other. At the low-frequency limit, the permittivity obtained from the extracellular-electrode-type calculations varied in proportion to the capacitance obtained from the intracellular-electrode-type ones. These results were consistent with conventional lumped and distributed circuit models for the T-tubules. This confirms that the interfacial polarization in the T-tubules in a single muscle cell is not sufficient to explain the experimental results in which the intensity of the α-relaxation in the extracellular-electrode-type experiments exceeded the intensity expected from the results of the intracellular-electrode-type experiments. The high-frequency relaxation term that was assigned to the β-relaxation was also affected by the T-tubule structure in the calculations relevant to the extracellular-electrode-type experiments. © 2007 Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/2297/3893
関連URI: http://dx.doi.org/10.1016/j.bioelechem.2007.01.001
http://www.elsevier.com/locate/issn/15675394
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文(医学・保健)

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