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タイトル: Preventive effect of pine bark extract (Flavangenol) on metabolic disease in western diet-loaded tsumura suzuki obese diabetes mice
著者: Shimada, Tsutomu link image link image
Kosugi, Mitsutaka
Tokuhara, Daisuke
Tsubata, Masahito
Kamiya, Tomoyasu
Sameshima, Mayu
Nagamine, Rika
Takagaki, Kinya
Miyamoto, Ken-ichi link image link image
Aburada, Masaki link image link image
嶋田, 努
宮本, 謙一
油田, 正樹
発行日: 2011年
出版社(者): Hindawi Publishing Corporation
雑誌名: Evidence-based Complementary and Alternative Medicine
ISSN: 1741-427X
巻: 2011
開始ページ: 185913
抄録: It is known that the metabolic syndrome has a multi-factorial basis involving both genetic and environmental risk factors. In this study, Tsumura Suzuki Obese Diabetes (TSOD) mice, a mouse model of multi-factorial, hereditary, obese type II diabetes, were given a Western diet (WTD) as an environmental factor to prepare a disease model (TSOD-WTD) and to investigate the preventive effects of Pine bark extract (Flavangenol) against obesity and various features of metabolic disease appearing in this animal model. In contrast to control Tsumura Suzuki Non-obesity (TSNO) mice, TSOD mice were obese and suffered from other metabolic complications. WTD-fed TSOD mice developed additional features such as hyperinsulinemia, abnormal glucose/lipid metabolism and fatty liver. The treatment with Flavangenol had a suppressive effect on increase in body weight and accumulation of visceral and subcutaneous fat, and also showed preventive effects on symptoms related to insulin resistance, abnormal glucose/lipid metabolism and hypertension. Flavangenol also increased the plasma concentration of adiponectin and decreased the plasma concentration of TNF-. We next investigated the effect of Flavangenol on absorption of meal-derived lipids. Flavangenol suppressed absorption of neutral fat in an olive-oil-loading test (in vivo) and showed an inhibitory effect on pancreatic lipase (in vitro). The above results suggest that Flavangenol has a preventive effect on severe metabolic disease due to multiple causes that involve both genetic and environmental risk factors. The mechanism of action might involve a partial suppressive effect of meal-derived lipids on absorption. Copyright © 2011 Tsutomu Shimada et al.
DOI: 10.1093/ecam/nep231
URI: http://hdl.handle.net/2297/39149
資料種別: Journal Article
権利関係: Copyright © 2011 Tsutomu Shimada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
版表示: publisher
出現コレクション:1. 査読済論文

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