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タイトル: Expression profiles of MUC mucin core protein in the intrahepatic biliary system: Physiological distribution and pathological significance
著者: 佐々木, 素子 link image link image
中沼, 安二 link image
Sasaki, Motoko
Ikeda, Hiroyuki
Nakanuma, Yasuni
発行日: 2005年
出版社(者): 日本組織細胞化学会
雑誌名: Acta Histochemica et Cytochemica
ISSN: 0044-5991
巻: 38
号: 5
開始ページ: 295
終了ページ: 303
キーワード: Biliary epithelial dysplasia
CDX2
Cholangiocarcinoma
Hepatolithiasis
MUC mucin core protein
抄録: Mucin secreted by mucosal epithelial cells plays a role in the protection of the mucosal surface and also is involved in pathological processes. So far, MUC1-4, 5AC, 5B, 6-8, 11-13 and 15-17 genes coding the backbone mucin core protein have been identified in humans. Their diverse physiological distribution and pathological alterations have been reported. We have studied the expression profiles of MUC genes in the intrahepatic biliary system in developmental, normal and diseased livers using immunohistochemistry and in situ hybridization. Fetal intrahepatic bile ducts and ductal plates frequently express MUC1, while intrahepatic large bile ducts after birth express mainly MUC3 mucin. In hepatolithiasis, MUC5AC (gastric foveolar epithelial type) and MUC6 (pyloric gland type) mucins are newly expressed in surface epithelial cells and proliferated peribiliary glands, respectively, and the expression of gel-forming mucin may play a role in lithogenesis. Most biliary epithelial dysplasias and cholangiocarcinomas associated with hepatolithiasis expressed MUC5AC, suggesting that intrahepatic bile ducts express the gastric foveolar phenotype during carcinogenesis. In addition, intestinal metaplasia, intraductal papillary tumor and mucinous carcinoma, characterized by MUC2 expression, are occasionally associated with hepatolithiasis in a CDX2 homeobox gene-dependent manner. These findings may suggest the presence of intestinal metaplasia-related carcinogenesis in the intrahepatic biliary system as in the stomach.
URI: http://hdl.handle.net/2297/6777
関連URI: http://www.jstage.jst.go.jp/article/ahc/38/5/295/_pdf
資料種別: Journal Article
権利関係: 日本組織細胞化学会の許諾を得て登録
版表示: publisher
出現コレクション:1. 査読済論文(医学・保健)

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