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タイトル: 99mTc-Annexin-V uptake in a rat model of variable ischemic severity and reperfusion time
著者: Taki, Junichi link image link image
Higuchi, Takahiro
Kawashima, Atsuhiro
Tait, Jonathan F.
Muramori, Akira
Matsunari, Ichiro
Nakajima, Kenichi link image link image
Vanderheyden, Jean-Luc
Strauss, H. William
瀧, 淳一
中嶋, 憲一
発行日: 2007年
出版社(者): 日本循環器学会
雑誌名: Circulation Journal
ISSN: 1346-9843
巻: 71
号: 7
開始ページ: 1141
終了ページ: 1146
キーワード: 99mTc-Annexin- V
Apoptosis imaging
Myocardial ischemia
Reperfusion
抄録: Background: To determine whether mild to moderate ischemia that is not severe enough to induce myocardial infarction will cause myocardial cell damage or apoptosis, the 99mTc-Annexin-V (Tc-A) uptake was studied in groups of rats with various intervals of coronary occlusion and reperfusion times. Methods and Results: After left coronary artery occlusion for 15 min (n=23), 10 min (n=23), or 5min (n=12), Tc-A (80-150 MBq) was injected at 0.5, 1.5, 6, or 24 h after reperfusion. One hour later, to verify the area at risk, 201Tl (0.74 MBq) was injected just after left coronary artery re-occlusion and the rats were killed 1 min later. Dual tracer autoradiography was performed to assess Tc-A uptake and area at risk. In all 5-min occlusion and reperfusion models, no significant Tc-A uptake was observed in the area at risk. Tc-A uptake ratios in the 15-min and 10-min ischemia models were 4.46±3.16 and 2.02±0.47 (p=0.078) at 0.5 h after reperfusion, 3.49±1.78 and 1.47±0.11 (p<0.05) at 1.5h after reperfusion, 1.60±0.43 and 1.34±0.23 (p=0.24) at 6h after reperfusion, 1.50±0.33 and 1.28±0.33 (p=0.099) at 24 h after reperfusion, respectively. With 15-min ischemia, in 3 of the 5 rats there were a few micro-foci of myocardial cell degeneration and cell infiltration in less than 1% of the ischemic area at 24 h after reperfusion. No significant histological change was observed in rats with 10-min or 5-min ischemia. Conclusion: The data indicate that Tc-A binding depends on the severity of ischemia even without a significant amount of histological change or infarction.
DOI: 10.1253/circj.71.1141
URI: http://hdl.handle.net/2297/6863
関連URI: http://www.jstage.jst.go.jp/article/circj/71/7/71_1141/_article
資料種別: Journal Article
版表示: publisher
出現コレクション:1. 査読済論文

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