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タイトル: Metabolic imaging using SPECT
著者: Taki, Junichi link image link image
Matsunari, Ichiro
瀧, 淳一
発行日: 2007年 6月
出版社(者): Springer Verlag
雑誌名: European Journal of Nuclear Medicine and Molecular Imaging
ISSN: 1619-7070
巻: 34
号: 1
開始ページ: S34
終了ページ: S48
キーワード: BMIPP
Cardiomyopathy
Coronary artery disease
Free fatty acid
Metabolic imaging
SPECT
抄録: Introduction: In normal condition, the heart obtains more than two-thirds of its energy from the oxidative metabolism of long chain fatty acids, although a wide variety of substrates such as glucose, lactate, ketone bodies and amino acids are also utilised. In ischaemic myocardium, on the other hand, oxidative metabolism of free fatty acid is suppressed and anaerobic glucose metabolism plays a major role in residual oxidative metabolism. Therefore, metabolic imaging can be an important technique for the assessment of various cardiac diseases and conditions. Materials and methods: In SPECT, several iodinated fatty acid traces have been introduced and studied. Of these, 123I-labelled 15-(p-iodophenyl)3-R, S-methylpentadecanoic acid (BMIPP) has been the most commonly used tracer in clinical studies, especially in some of the European countries and Japan. Results and discussion: In this review article, several fatty acid tracers for SPECT are characterised, and the mechanism of uptake and clinical utility of BMIPP are discussed in detail. © 2007 Springer-Verlag.
DOI: 10.1007/s00259-007-0439-9
URI: http://hdl.handle.net/2297/6864
資料種別: Journal Article
版表示: author
出現コレクション:1. 査読済論文

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