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タイトル: Gender difference in coronary events in relation to risk factors in Japanese hypercholesterolemic patients treated with low-dose simvastatin
著者: Sasaki, Jun
Kita, Toru
Mabuchi, Hiroshi link image
Matsuzaki, Masunori
Matsuzawa, Yuji
Nakaya, Noriaki
Oikawa, Shinichi
Saito, Yasushi
Shimamoto, Kazuaki
Kono, Suminori
Itakura, Hiroshige
馬渕, 宏
松崎, 益徳
発行日: 2006年
出版社(者): 日本循環器学会
雑誌名: Circulation Journal
ISSN: 1346-9843
巻: 70
号: 7
開始ページ: 810
終了ページ: 814
キーワード: Coronary events
Hyperlipidemia
Risk factors
Serum cholesterol
Sex differences
抄録: Background: Gender differences between the risk factors for coronary heart disease and coronary events were examined in the Japan Lipid Intervention Trial, a 6-year observational study. Methods and Results Men (12,575) and women (27,013) were analyzed for risk of coronary events (acute myocardial infarction and sudden cardiac death). Simvastatin reduced serum low-density lipoprotein cholesterol (LDL-C) by 27% in both genders, and increased serum high-density lipoprotein cholesterol (HDL-C) in men (5%) and women (4%). The incidence of coronary events was lower in women (0.64/1,000 patient-years) than in men (1.57/1,000 patient-years). The risk of coronary events increased by 18% in men and 21% in women with each 10 mg/dl elevation of LDL-C, and decreased by 39% in men and 33% in women with each 10 mg/dl elevation of HDL-C. The risk increased proportionally with aging in women, but not in men. Diabetes mellitus (DM) was more strongly related to the risk of coronary events for women (relative risk 3.07) than for men (relative risk 1.58). Conclusions: The incidence of coronary events is lower in women. Serum LDL-C is related to an increased risk of coronary events to the same extent in both genders. DM seems to be a more important risk factor in women, trading off the lower risk of coronary events among them.
DOI: 10.1253/circj.70.810
URI: http://hdl.handle.net/2297/7199
資料種別: Journal Article
版表示: publisher
出現コレクション:1. 査読済論文(医学・保健)

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