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タイトル: Type III hyperlipoproteinemia exaggerated by Sheehan's syndrome with advanced systemic atherosclerosis - A 28-year clinical course
著者: Kawashiri, Masaaki link image link image
Higashikata, Toshinori
Takata, Mutsuko
Katsuda, Shoji
Miwa, Kenji
Nohara, Atsushi link image link image
Inazu, Akihiro link image link image
Kobayashi, Junji link image
Shimizu, Masami
Koizumi, Junji link image
Mabuchi, Hiroshi link image
川尻, 剛照
野原, 淳
稲津, 明広
小林, 淳二
馬渕, 宏
清水, 賢巳
発行日: 2005年 6月
出版社(者): 日本循環器学会
雑誌名: Circulation Journal
ISSN: 1346-9843
巻: 69
号: 6
開始ページ: 746
終了ページ: 751
キーワード: Atherosclerosis
Remnant lipoprotein
Sheehan's syndrome
Type III hyperlipoproteinemia
抄録: A 38-year-old Japanese woman was admitted to hospital for further examination of systemic xanthomas. She had a past history of genital bleeding during her third delivery at the age of 21 years. She was diagnosed with Sheehan's syndrome. Her serum total cholesterol and triglyceride concentrations were 500 and 898 mg/dl, respectively. She was also diagnosed as having type III hyperlipoproteinemia on the basis of the presence of a broad-β-band on agarose gel electrophoresis and extremely high concentrations of very-low-density lipoprotein cholesterol (310 mg/dl). The diagnosis was later confirmed by her apolipoprotein E isoforms (E2/E2) and genotypes (epsilon2/epsilon2). Thyroid and corticosteroid hormone replacement therapy cured the xanthomas, but also elevated her blood pressure. The serum concentration of intermediate-density lipoprotein cholesterol was consistently high, whereas that of low-density lipoprotein cholesterol was relatively low during the follow-up. Coronary atherosclerosis had already developed by the age of 38 years, and progressed significantly over the following 28 years. Severe stenotic lesions were observed in the bilateral renal arteries and carotid arteries, and in the abdominal aorta when she was 66 years old. These findings suggest that the continuous elevation of intermediate-density lipoprotein cholesterol for a long period contributed to the development of the atherosclerotic lesions.
DOI: 10.1253/circj.69.746
URI: http://hdl.handle.net/2297/7216
資料種別: Journal Article
権利関係: 日本循環器学会の許諾を得て登録
版表示: publisher
出現コレクション:1. 査読済論文(医学・保健)

このアイテムを引用あるいはリンクする場合は次の識別子を使用してください。 http://hdl.handle.net/2297/7216



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