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タイトル: Q-T peak dispersion in congenital long QT syndrome: Possible marker of mutation of HERG
著者: Inoue, Masaru
Shimizu, Masami
Ino, Hidekazu
Yamaguchi, Masato link image
Terai, Hidenobu link image
Hayashi, Kenshi link image link image
Kiyama, Masaru
Sakata, Kenji
Hayashi, Tatsumi
Mabuchi, Hiroshi link image
清水, 賢巳
井野, 秀一
坂田, 憲治
馬渕, 宏
発行日: 2003年 6月
出版社(者): 日本循環器学会
雑誌名: Circulation Journal
ISSN: 1346-9843
巻: 67
号: 6
開始ページ: 495
終了ページ: 498
キーワード: HERG
Long QT syndrome
Notched T wave
QT dispersion
抄録: Congenital long QT syndrome (LQTS) is caused by mutations in various cardiac potassium or sodium channel genes, with 6 different genotypes thus far identified. However, it is unknown whether these genotypes can be differentiated by QT variables. The electrocardiograms obtained from 16 patients with a mutation in KCNQ1 (LQT1), 7 patients with a mutation in HERG (LQT2) and 20 control subjects were analyzed. The corrected QT interval (QTc), Q-T peak interval (QTpc) and dispersion of QTc or QTpc were measured in 6 precordial leads. The corrected interval from T peak to T end (Tpec) was measured in lead V5. The maximum QTc, QTc dispersion, and Tpec were significantly increased in the LQT1 and LQT2 patients than in the controls. However, there were no significant differences in these indices between the LQT1 and LQT2 patients. In contrast, QTpc dispersion was significantly increased in the LQT2 patients (78±25 ms) compared with the LQT1 patients (29±15 ms) and controls (26±19 ms). These results suggest that increased lag of the peak of the T wave in each precordial lead (QTpc dispersion) may be a possible index to differentiate LQTS patients with HERG mutation from those with KCNQ1 mutation.
URI: http://hdl.handle.net/2297/7524
関連URI: http://www.jstage.jst.go.jp/article/circj/67/6/495/_pdf
資料種別: Journal Article
版表示: publisher
出現コレクション:1. 査読済論文(医学・保健)

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