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タイトル: Perfusable tissue index obtained by positron emission tomography as a marker of myocardial viability in patients with ischemic ventricular dysfunction
著者: Itoh, Hideki
Namura, Masanobu
Seki, Hiroyuki
Asai, Toru
Tsuchiya, Taketsugu
Uenishi, Hiroaki
Fujii, Hiroyuki
Fujita, Shinichiro
Tanabe, Yujirou
Ito, Jun
Shimizu, Masami
Mabuchi, Hiroshi link image
清水, 賢巳
馬渕, 宏
発行日: 2002年
出版社(者): 日本循環器学会
雑誌名: Circulation Journal
ISSN: 1346-9843
巻: 66
号: 4
開始ページ: 341
終了ページ: 344
キーワード: Hibernation
Myocardial viability
Perfusable tissue index
Positron emission tomography
Ventricular dysfunction
抄録: In areas of severe asynergy, the clinically important task is to identify functionally recoverable myocardium. Fourteen patients with asynergy were investigated by H215O dynamic positron emission tomography imaging before revascularization. Regional myocardial blood flow (MBF) was determined and the water-perfusable tissue fraction (PTF) for each region of interest and the total anatomical tissue fraction (ATF) were estimated. The PTF/ATF was analyzed as the water perfusable tissue index (PTI). Asynergy was defined as segments with wall motion more than 2 SD below than that of a normal population. An increase of >0.8 SD in anterior wall segments with asynergy and an increase of >0.6 SD in inferior wall asynergy were defined as significant improvements of wall motion indicative of viable myocardium. Fifteen segments with wall motion abnormalities less than -2 SD and 10 control segments were identified; 7 segments recovered and 8 segments did not. MBF was similar in both groups of segments before revascularization (0.78±0.27 vs 0.73±0.18 ml · min-1 · g-1, NS). The PTI in the recovered segments was significantly higher than that in the unimproved segments (0.734±0.058 vs 0.592±0.038, p<0.0001) and was similar to that of the control segments. After revascularization, the PTI correlated with the SD of wall motion (p<0.05, r=0.58). PTI may be a good predictor of contractile recovery after revascularization.
DOI: 10.1253/circj.66.341
URI: http://hdl.handle.net/2297/7525
関連URI: http://www.jstage.jst.go.jp/article/circj/66/4/66_341/_article/-char/en
資料種別: Journal Article
版表示: publisher
出現コレクション:1. 査読済論文(医学・保健)

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